Atypical Glandular Cells (AGC): Causes, Symptoms, and Treatment

Atypical Glandular Cells (AGC): Causes, Symptoms, and Treatment

Article
Focused Health Topics
Women's Health
+1
Contributed byKrish Tangella MD, MBA+1 moreApr 16, 2023

Introduction:

Atypical glandular cells (AGC) is a term used to describe abnormal cells found in a cervical Pap test. These cells may indicate the presence of cervical or endometrial cancer, or they may be a result of benign changes in the cervix. In this article, we will discuss the causes, symptoms, and treatment of atypical glandular cells.

Causes:

Atypical glandular cells can be caused by a variety of factors, including:

  • Human papillomavirus (HPV) infection
  • Endometrial hyperplasia or cancer
  • Cervical cancer
  • Uterine fibroids or polyps
  • Menopause or perimenopause
  • Hormonal changes
  • Infection or inflammation of the cervix or uterus

Symptoms:

Atypical glandular cells do not typically cause symptoms. In some cases, women may experience abnormal vaginal bleeding or discharge, pelvic pain, or pain during sex, which may be indicative of cervical or endometrial cancer.

Diagnosis:

Atypical glandular cells are typically diagnosed through a Pap test, which involves taking a sample of cells from the cervix and examining them under a microscope for abnormalities. Women with AGC may be referred for additional testing, including colposcopy, which involves examining the cervix with a special magnifying device, or a biopsy, which involves taking a sample of tissue for further examination.

Treatment:

The treatment for atypical glandular cells depends on the underlying cause. For benign changes in the cervix or uterus, close monitoring and follow-up Pap tests may be recommended. For more serious conditions, such as cervical or endometrial cancer, treatment may involve surgery, radiation therapy, chemotherapy, or a combination of these treatments.

Prevention:

Preventing atypical glandular cells involves taking steps to reduce the risk of cervical and endometrial cancer. This includes getting regular Pap tests, practicing safe sex to reduce the risk of HPV infection, and maintaining a healthy lifestyle, including a balanced diet and regular exercise.

Conclusion:

Atypical glandular cells can be a result of benign changes in the cervix or may indicate the presence of cervical or endometrial cancer. Diagnosis typically involves a Pap test and may require additional testing. Treatment depends on the underlying cause and may involve surgery, radiation therapy, chemotherapy, or a combination of these treatments. Preventing atypical glandular cells involves getting regular Pap tests, practicing safe sex, and maintaining a healthy lifestyle.

Hashtags: #atypicalglandularcells #cervicalcancer #endometrialcancer #Paptest #colposcopy #biopsy #treatment #prevention

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On the Article

Krish Tangella MD, MBA picture
Author

Krish Tangella MD, MBA

Pathology, Medical Editorial Board, DoveMed Team
Alexandra Warren picture
Author

Alexandra Warren

Senior Editorial Staff

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