What are the other Names for this Condition? (Also known as/Synonyms)

• NDH (Neutrophilic Dermatosis of the Hand)
• Neutrophilic Dermatosis of Hands
• Neutrophilic Dermatosis of the Dorsal Hands

What is Neutrophilic Dermatosis of the Hand? (Definition/Background Information)

• Neutrophilic Dermatosis of the Hand (NDH) is a rare and poorly understood dermatological condition that primarily affects the hands. It is characterized by the sudden onset of painful, red, and swollen lesions on the fingers and palms, which can progress to form pustules or blisters
• Neutrophilic Dermatosis of the Hand is a type of neutrophilic dermatosis, a group of skin disorders characterized by the infiltration of neutrophils into the skin. It is described as a localized variant of Sweet’s syndrome
• The exact cause of Neutrophilic Dermatosis of the Hand is unknown. Still, it is believed to be related to an abnormal immune response or a reaction to medications or other triggers. NDH has been associated with autoimmune diseases, such as rheumatoid arthritis and lupus
• Neutrophilic Dermatosis of the Hand is diagnosed by a dermatologist based on the appearance of the skin (physical examination) and medical history. A skin biopsy may also be performed to confirm the diagnosis
• The treatment typically involves a combination of topical and oral medications, including wound care and management. The prognosis of Neutrophilic Dermatosis of the Hand varies on a case-by-case basis depending on its severity

Who gets Neutrophilic Dermatosis of the Hand? (Age and Sex Distribution)

• Neutrophilic Dermatosis of the Hand is rare and can affect individuals of all ages and genders
• It is more common in women than men
• No racial or ethnic group predilection has been determined

What are the Risk Factors for Neutrophilic Dermatosis of the Hand? (Predisposing Factors)

Some potential risk factors for Neutrophilic Dermatosis of the Hand may include:

• Autoimmune diseases, such as rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE)
• A family history of autoimmune diseases or other skin conditions
• A history of medication use or exposure to chemicals or irritants

It is important to note that having a risk factor does not mean that one will get the condition. A risk factor increases one’s chances of getting a condition compared to an individual without the risk factors. Some risk factors are more important than others. 

Also, not having a risk factor does not mean that an individual will not get the condition. It is always important to discuss the effect of risk factors with your healthcare provider.

What are the Causes of Neutrophilic Dermatosis of the Hand? (Etiology)

Currently, the exact cause of Neutrophilic Dermatosis of the Hand is not well understood. It is believed to be related to an abnormal immune response or a reaction to medications or other triggers.

Some potential triggers may include:

• Infections
• Use of certain medications such as antibiotics or nonsteroidal anti-inflammatory drugs (NSAIDs)
• Exposure to chemicals or irritants
• Stress or trauma

What are the Signs and Symptoms of Neutrophilic Dermatosis of the Hand?

The signs and symptoms of Neutrophilic Dermatosis of the Hand (NDH) may vary from one individual to another. Some common signs and symptoms of NDH include:

• Sudden onset of painful, red, and swollen lesions on the fingers and palms
• Development of pustules or blisters
• Ulceration or crusting of the skin
• Itching or burning sensation
• In severe cases, fever or other systemic symptoms

How is Neutrophilic Dermatosis of the Hand Diagnosed?

• Neutrophilic Dermatosis of the Hand is typically diagnosed by a dermatologist based on a physical examination and medical history evaluation
• A skin biopsy may also be performed to confirm the diagnosis and rule out other conditions

Many clinical conditions may have similar signs and symptoms. Your healthcare provider may perform additional tests to rule out other clinical conditions to arrive at a definitive diagnosis.

What are the possible Complications of Neutrophilic Dermatosis of the Hand?

If left untreated, Neutrophilic Dermatosis of the Hand can lead to the following complications:

• Scarring and deformity of the hands
• Functional impairment of the hands
• It may also increase the risk for infections and other medical complications

How is Neutrophilic Dermatosis of the Hand Treated?

The treatment for Neutrophilic Dermatosis of the Hand may include:

• Topical or oral corticosteroids to reduce inflammation and pain
• Immunosuppressive medications, such as methotrexate or cyclosporine, to suppress the immune system
• Antibiotics to treat any underlying infections
• Wound care and management to prevent infection and promote healing

How can Neutrophilic Dermatosis of the Hand be Prevented?

Currently, no measures are available to prevent Neutrophilic Dermatosis of the Hand. However, some strategies that may help include:

• Avoiding exposure to chemicals or irritants
• Prompt treatment of any underlying infections or medical conditions (autoimmune diseases)
• Close monitoring of medications for any potential side effects or reactions

What is the Prognosis of Neutrophilic Dermatosis of the Hand? (Outcomes/Resolutions)

The prognosis for Neutrophilic Dermatosis of the Hand (NDH) varies depending on the severity and duration of the condition.

• With appropriate treatment, most cases of NDH can be managed effectively and result in a full recovery
• However, some individuals may require ongoing treatment or may experience recurrent episodes of the condition

Additional and Relevant Useful Information for Neutrophilic Dermatosis of the Hand:

The following link is a useful resource for information on Sweet’s syndrome:

https://www.dovemed.com/diseases-conditions/sweets-syndrome/