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First Aid for Piroxicam Overdose

Last updated Feb. 23, 2018

Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) that is used for treating various conditions that affect the joints including rheumatoid arthritis (RA), ankylosing spondylitis, and osteoarthritis. Piroxicam Overdose is the accidental or intentional intake of the drug in dosage higher than prescribed values.


What is Piroxicam Overdose?

  • Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) that is used for treating various conditions that affect the joints including rheumatoid arthritis (RA), ankylosing spondylitis, and osteoarthritis. The drug has antipyretic, anti-inflammatory, and analgesic properties
  • Piroxicam Overdose is the accidental or intentional intake of the drug in dosage higher than prescribed values
  • The condition is diagnosed based upon the clinical history, combination of signs and symptoms, and additional tests (that may include, in some cases, radiological studies and laboratory tests)

Piroxicam Overdose may be also referred to as Feldene Overdose.

What are the Causes of Piroxicam Overdose?

  • Piroxicam Overdose is caused by the intake of piroxicam containing drug in dosage that is higher than prescribed
  • This intake could be accidental, or in some cases intentional, to bring self-harm

Note: The drug can interact with other prescribed or non-prescribed medications in the body. Such interactions may enhance the therapeutic effects of the drug or other medications being taken, resulting in undesired side effects (such as an overdose).

What are the Signs and Symptoms of Piroxicam Overdose?

The signs and symptoms of Piroxicam Overdose can vary from one individual to another. It may be mild in some and severe in others. Several systems of the body, such as the respiratory system, digestive system, nervous system, skin and ENT may be affected.

The signs and symptoms of Piroxicam Overdose may include:

  • Nausea, vomiting
  • Diarrhea
  • Heartburn
  • Bleeding in the stomach, stomach pain
  • Breathing difficulties including wheezing
  • Lack of coordinated movements
  • Mumbling or incoherence
  • Confusion and increased nervousness
  • Seizures
  • Rashes on the skin
  • Ringing in the ears
  • Vision abnormalities including blurred vision
  • Coma

How is First Aid administered for Piroxicam Overdose?

First Aid tips for Piroxicam Overdose:

  • If the individual with Piroxicam Overdose is in a coma, or is experiencing life-threatening symptoms, call 911 (or your local emergency help number) immediately
  • Call the Poison Control Center at 1-800-222-1222 (or your local poison control center) for further instructions
  • Provide them with information such as dosage, type of drug taken, strength and time of ingestion of medication, age, weight and general health status of affected individual
  • Confirm that the airways are protected; also, ensure breathing and the presence of pulse
  • Take individual to emergency room (ER) for further treatment
  • Always try to take the medication strip/bottle/container to the ER

The emergency medical health professional might perform the following steps towards treating the condition:

  • Medically manage symptoms; provide breathing support, if necessary
  • Administer activated charcoal to avoid absorbance of drug in the body
  • Administer laxatives for elimination of drug from the body
  • Administer fluids by an intravenous drip line

Who should administer First Aid for Piroxicam Overdose?

First aid for Piroxicam Overdose is administered by healthcare professionals.

  • The individual who overdosed, or someone near, should call 911 for emergency assistance (or the local emergency number)
  • They should also call the poison control center at 1-800-222-1222 (or the local poison control center) and follow instructions

What is the Prognosis of Piroxicam Overdose?

In most cases, Piroxicam Overdose is usually not a life-threatening condition and once symptoms are managed, the prognosis is good.

  • Nevertheless, the prognosis of Piroxicam Overdose is dependent on the amount of drug consumed, time between overdose and treatment, severity of the symptoms, as well as general health status of the patient
  • In case of severe symptoms including seizures, and coma, it may considerably worsen the outcome. Severe cases of overdose (due to ingestion of large amounts of the drug) are known to be fatal

In general, overdoses are common situations in the emergency departments. A majority of the cases are often not fatal, when appropriate treatment is given.

How can Piroxicam Overdose be Prevented?

Piroxicam Overdose can be prevented by:

  • Always taking the right dose of medication at recommended times
  • Avoiding drugs that might interact with piroxicam
  • Talking to your healthcare provider, if recommended dose of piroxicam does not provide relief
  • Refrain from self-medication
  • Exercising caution while taking multiple drugs with piroxicam
  • Keeping medications out of reach of children in child-proof containers
  • For older individuals and those who tend to be forgetful, medications should be stored in single dose containers with time labels, to avoid multiple dosage
  • Monitor intake of this drug especially in patients, who have depression or harbor suicidal thoughts and behavior

It is important to give your healthcare provider a complete list of prescription and non-prescription medications that are being currently taken. This will help them in assessing the possible drug interactions within various medications and help avoid/prevent accidental or unintentional toxic drug effects.

What are certain Crucial Steps to be followed?

  • Call 911 (or your local emergency number) for emergency assistance, if symptoms are life-threatening
  • Call Poison Control Center at 1-800-222-1222 (or the local poison control center) and follow the recommend steps
  • It would be helpful if the following information is readily available:
    • Type, dosage and time of administration of medication
    • Age and weight of the individual
    • And, the overall health status of the individual

What are some Useful Resources for Additional Information?


References and Information Sources used for the Article:


Helpful Peer-Reviewed Medical Articles:


Reviewed and Approved by a member of the DoveMed Editorial Board
First uploaded: July 5, 2017
Last updated: Feb. 23, 2018