What are the other Names for this Condition? (Also known as/Synonyms)

• Neurogenic Hypotension
• Neurogenic Postural Hypotension

What is Neurogenic Orthostatic Hypotension? (Definition/Background Information)

• Neurogenic Orthostatic Hypotension is a type of dysautonomia characterized by a significant drop in blood pressure upon standing, caused by dysfunction in the autonomic nervous system's ability to regulate blood vessel constriction and heart rate in response to postural changes
• It is a form of dysautonomia, with signs and symptoms that include dizziness, lightheadedness, blurred vision, and fainting. A diagnosis of Neurogenic Orthostatic Hypotension involves clinical evaluation, autonomic function testing, and ruling out other causes
• The treatment of Neurogenic Orthostatic Hypotension may include lifestyle adjustments, increased fluid and salt intake, medications, and physical maneuvers to alleviate symptoms. The prognosis varies, with some individuals achieving improved symptom management and quality of life through treatment

Who gets Neurogenic Orthostatic Hypotension? (Age and Sex Distribution)

• Neurogenic Orthostatic Hypotension can affect individuals of any age, but it is more commonly seen in older adults
• It may occur in both men and women, although some specific forms may have a slight male predominance
• The condition may occur worldwide, affecting individuals of all racial and ethnic groups

What are the Risk Factors for Neurogenic Orthostatic Hypotension? (Predisposing Factors)

The risk factors of Neurogenic Orthostatic Hypotension may include:

• Age: Older age increases the risk of developing Neurogenic Orthostatic Hypotension
• Neurological conditions: Certain neurological disorders such as Parkinson's disease, multiple system atrophy, and pure autonomic failure increase the risk
• Medications: Certain medications used to treat high blood pressure or neurological conditions can contribute to orthostatic hypotension

It is important to note that having a risk factor does not mean that one will get the condition. A risk factor increases one’s chances of getting a condition compared to an individual without the risk factors. Some risk factors are more important than others.

Also, not having a risk factor does not mean that an individual will not get the condition. It is always important to discuss the effect of risk factors with your healthcare provider.

What are the Causes of Neurogenic Orthostatic Hypotension? (Etiology)

Neurogenic Orthostatic Hypotension is a condition characterized by a drop in blood pressure upon standing or assuming an upright position.

• The condition is primarily caused by dysfunction of the autonomic nervous system, which regulates blood pressure and heart rate, leading to inadequate blood flow to the brain and other organs when changing positions
• Specific underlying causes may include degenerative neurological diseases, nerve damage, or certain medications

What are the Signs and Symptoms of Neurogenic Orthostatic Hypotension?

The signs and symptoms of Neurogenic Orthostatic Hypotension may be mild or severe and can vary from one individual to another. These may include:

• Dizziness or lightheadedness upon standing
• Fainting or syncope
• Blurred vision
• Weakness or fatigue
• Difficulty concentrating
• Headaches

How is Neurogenic Orthostatic Hypotension Diagnosed?

A diagnosis of Neurogenic Orthostatic Hypotension may involve the following tests and exams:

• Medical history and symptom assessment: The physician may inquire about symptoms and medical history
• Physical examination: Blood pressure measurements in different positions (lying, sitting, standing) are taken to observe the blood pressure changes
• Tilt table test: A specialized test where the person is tilted at different angles to assess blood pressure and heart rate responses
• Autonomic function tests: These tests evaluate the autonomic nervous system's function, which can help identify the underlying cause
• Laboratory tests and radiological imaging studies, as needed

Many clinical conditions may have similar signs and symptoms. Your healthcare provider may perform additional tests to rule out other clinical conditions to arrive at a definitive diagnosis.

What are the possible Complications of Neurogenic Orthostatic Hypotension?

The complications of Neurogenic Orthostatic Hypotension may include:

• Falls and injuries: Due to the risk of fainting or dizziness, individuals with neurogenic orthostatic hypotension are at an increased risk of falls and related injuries
• Reduced quality of life: The symptoms and limitations imposed by orthostatic hypotension can affect daily activities and overall quality of life

How is Neurogenic Orthostatic Hypotension Treated?

The treatment of Neurogenic Orthostatic Hypotension may involve the following measures:

• Lifestyle modifications: Increasing fluid and salt intake, wearing compression stockings, and making postural changes slowly can help manage symptoms
• Medications: Various medications may be prescribed to raise blood pressure or improve the autonomic nervous system function

How can Neurogenic Orthostatic Hypotension be Prevented?

• Prevention strategies for Neurogenic Orthostatic Hypotension primarily focus on managing the underlying conditions contributing to autonomic dysfunction
• Regular medical check-ups and adherence to treatment plans are essential

What is the Prognosis of Neurogenic Orthostatic Hypotension? (Outcomes/Resolutions)

• The prognosis of Neurogenic Orthostatic Hypotension depends on the underlying cause and the effectiveness of the treatment
• With appropriate management, symptoms can be controlled, improving quality of life and reducing the risk of complications

Additional and Relevant Useful Information for Neurogenic Orthostatic Hypotension:

The following DoveMed website link is a useful resource for additional information:

http://www.dovemed.com/diseases-conditions/rare-disorders/