What are the other Names for this Condition? (Also known as/Synonyms)

• LELC (Lymphoepithelioma-like Urothelial Carcinoma)
• LELCB (Lymphoepithelioma-like Carcinoma of the Bladder)
• Lymphoepithelioma-like Carcinoma of the Bladder (LELCB)

What is Lymphoepithelioma-like Urothelial Carcinoma? (Definition/Background Information)

• Lymphoepithelioma-like Urothelial Carcinoma (LELC) is a rare subtype of invasive urothelial carcinoma, a form of malignancy of the urothelium (urothelial cells that line the urothelial tract). The site of LELC may commonly include the urinary bladder
• Lymphoepithelioma-like Urothelial Carcinoma is diagnosed under the microscope, on examination of the cancer cells by a pathologist. The classification of the tumor is important, as it may dictate the type of treatments to be provided and the overall outcomes. The prognosis typically depends on the percentage of lymphoepithelioma component in the tumor (pure variants are known to have improved outcomes)
• The exact cause of Lymphoepithelioma-like Urothelial Carcinoma is presently unknown; abnormalities in the p53 gene are reported. The condition is frequently noted in men. Many contributory factors, such as smoking (a significant risk factor), occupational exposure to chemicals, and prior radiation therapy, are noted. Epstein-Barr virus (EBV) and human papillomavirus (HPV) infections are not associated with LELC
• The signs and symptoms of Lymphoepithelioma-like Urothelial Carcinoma usually include blood in urine (hematuria), burning sensation on urination, back pain, and urinary tract infections. During its advanced stages, the cancer may metastasize to the lymph nodes and other organs. When examined under the microscope by a pathologist, this type of cancer has histological features similar to nasopharyngeal lymphoepithelioma
• The treatment may include surgery (transurethral resection of bladder tumor) and radiation therapy based on the healthcare provider’s assessment. Patients find chemotherapy a beneficial treatment modality. The prognosis of Lymphoepithelioma-like Urothelial Carcinoma is known to be variable; meaning it varies from one individual to another, but is mostly favorable