What are the other Names for this Condition? (Also known as/Synonyms)

• Adenocarcinoma In Situ, HPV-Associated, of the Uterine Cervix
• HPV-Associated Cervical Adenocarcinoma In Situ
• Human Papillomavirus Associated AIS of the Uterine Cervix

What is HPV-Associated Adenocarcinoma In Situ of the Uterine Cervix? (Definition/Background Information)

• HPV-Associated Adenocarcinoma In Situ of the Uterine Cervix is a premalignant condition and a precursor to cervical cancer. Cervical cancer is a malignancy of the uterine cervix, which is the lower part of the uterus/womb. It is a very common cancer in women worldwide. The cervix is the tube-like structure that connects the uterus to the vagina. Almost all cervical cancers are believed to originate from a premalignant lesion
• The development of cervical cancer occurs slowly and the process of precancerous changes leading to invasive cancer, generally takes place over decades. Hence, periodic screening of women with Pap smears helps in early detection and management of any precancerous change, before a full-blown malignancy develops. Cervical cancer is frequently preventable through early screening programs and HPV vaccinations
• Adenocarcinoma in situ (AIS) of cervix is a small-sized, localized, premalignant adenocarcinoma, observed in the uterine cervix. These often involve small-sized areas of the cervix. It may be described as an epithelial lesion and carries a very high-risk for invasive carcinoma, if left untreated. The condition is also known as high-grade cervical glandular intraepithelial neoplasia (HG-CGIN)
• HPV-Associated Adenocarcinoma In Situ of the Uterine Cervix is the development of preinvasive carcinoma due to persistent/recurrent human papillomavirus (HPV) infection. It is reported that about 90% of cervical adenocarcinoma in situ cases are HPV-associated, with the mean age of diagnosis being 30-40 years
• HPV infection is transmitted sexually, and high-risk HPV types (mainly HPV strains 16, 18, and 45) are responsible for nearly 90% of the cervical AIS cases. HPV-Associated Adenocarcinoma In Situ of the Uterine Cervix develops from precancerous lesions over many years, aided by factors such as the use of oral contraceptives, poor immunity, and smoking. Certain genes are known to be involved in the process, but these are not presently well-characterized
• In many women, AIS of the uterine cervix does not present any signs and symptoms. In rare cases, the presentations may include vaginal discharge, abnormal bleeding, and HPV infection causing genital warts. The diagnosis of HPV-Associated Adenocarcinoma In Situ of the Uterine Cervix is often difficult due to its location in the endocervical canal. Pap smear screenings, HPV testing, and colposcopy are helpful in detecting AIS of the cervix
• The treatments vary widely from conservative management of the condition to surgical removal of the abnormal tissue (through loop excision). The prognosis of HPV-Associated Adenocarcinoma In Situ of the Uterine Cervix is generally good with adequate treatment. It is important to have regular checkups to detect recurrences early. In case of a late diagnosis of AIS, there is a high risk for the development of invasive adenocarcinoma