Generalized Discoid Lupus Erythematosus

Generalized Discoid Lupus Erythematosus

Article
Skin Care
Diseases & Conditions
+1
Contributed byLester Fahrner, MD+1 moreAug 14, 2023

What are the other Names for this Condition? (Also known as/Synonyms)

  • Chronic Discoid Lupus Erythematosus
  • Generalized DLE

What is Generalized Discoid Lupus Erythematosus? (Definition/Background Information)

  • Generalized Discoid Lupus Erythematosus (Generalized DLE) is a chronic autoimmune skin condition characterized by widespread red, scaly, and coin-shaped plaques on various areas of the body. The other signs and symptoms include skin rash, photosensitivity, and potential scarring
  • Generalized Discoid Lupus Erythematosus is a form of cutaneous lupus erythematosus (CLE), affecting mainly the skin. It belongs to the subtype of CLE  termed chronic cutaneous lupus erythematosus (CCLE). The condition is typically observed in adults
  • Diagnosing this skin condition involves clinical evaluation, laboratory tests, and skin biopsies. The treatment of Generalized Discoid Lupus Erythematosus may involve topical or systemic medications to manage inflammation and symptoms
  • The prognosis of this cutaneous condition varies; while Generalized Discoid Lupus Erythematosus is generally not life-threatening, long-term management is often necessary to control symptoms, prevent complications, and minimize scarring

Who gets Generalized Discoid Lupus Erythematosus? (Age and Sex Distribution)

  • Generalized Discoid Lupus Erythematosus can affect individuals of all ages, but it is more commonly diagnosed in adults
  • It can occur in both males and females
  • Worldwide, no particular race or ethnicity preference is observed

What are the Risk Factors for Generalized Discoid Lupus Erythematosus? (Predisposing Factors)

  • The specific risk factors for Generalized Discoid Lupus Erythematosus are not well-established, but genetic and environmental factors may contribute to its development

It is important to note that having a risk factor does not mean that one will get the condition. A risk factor increases one’s chances of getting a condition compared to an individual without the risk factors. Some risk factors are more important than others.

Also, not having a risk factor does not mean that an individual will not get the condition. It is always important to discuss the effect of risk factors with your healthcare provider.

What are the Causes of Generalized Discoid Lupus Erythematosus? (Etiology)

The exact cause of Generalized Discoid Lupus Erythematosus is not fully understood, but it is considered to be an autoimmune disorder in which the body's immune system attacks its own skin cells.

What are the Signs and Symptoms of Generalized Discoid Lupus Erythematosus?

The signs and symptoms of Generalized Discoid Lupus Erythematosus may include:

  • Widespread red, scaly, and thickened patches on the skin
  • Circular or coin-shaped lesions with well-defined borders
  • Itching and discomfort
  • Lesions that heal with scarring and pigmentary changes
  • Scarring and hair loss in affected skin

How is Generalized Discoid Lupus Erythematosus Diagnosed?

A diagnosis of Generalized Discoid Lupus Erythematosus may involve the following exams and tests:

  • Physical examination of the skin and affected areas
  • Blood tests to detect specific autoantibodies and assess organ function
  • Skin biopsy for microscopic examination of skin tissue

Many clinical conditions may have similar signs and symptoms. Your healthcare provider may perform additional tests to rule out other clinical conditions to arrive at a definitive diagnosis.

What are the possible Complications of Generalized Discoid Lupus Erythematosus?

The complications of Generalized Discoid Lupus Erythematosus may include infection, scarring, and potential psychological impact due to visible skin changes.

How is Generalized Discoid Lupus Erythematosus Treated?

The treatment of Generalized Discoid Lupus Erythematosus may involve:

  • Topical corticosteroids to reduce inflammation and promote healing
  • Sun protection and avoiding known triggers
  • Immunosuppressive medications for more severe cases

How can Generalized Discoid Lupus Erythematosus be Prevented?

There is no known method to prevent Generalized Discoid Lupus Erythematosus, but sun protection and early treatment may help reduce the severity of symptoms.

What is the Prognosis of Generalized Discoid Lupus Erythematosus? (Outcomes/Resolutions)

  • The prognosis of Generalized Discoid Lupus Erythematosus is generally good with proper management and adherence to treatment
  • Most individuals can achieve control over their symptoms and prevent flare-ups

Additional and Relevant Useful Information for Generalized Discoid Lupus Erythematosus:

  • Cutaneous lupus erythematosus (CLE) constitutes a wide group of autoimmune disorders primarily affecting the skin. It may or may not be associated with systemic lupus erythematosus (SLE), which may cause systemic symptoms involving the entire body and several important organs

Read more about the condition at the following link:

https://www.dovemed.com/diseases-conditions/cutaneous-lupus-erythematosus/

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On the Article

Krish Tangella MD, MBA picture
Approved by

Krish Tangella MD, MBA

Pathology, Medical Editorial Board, DoveMed Team
Lester Fahrner, MD picture
Reviewed by

Lester Fahrner, MD

Chief Medical Officer, DoveMed Team

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