What are the other Names for this Condition? (Also known as/Synonyms)

• Foveolar-type Adenoma of Stomach
• Gastric Adenoma, Foveolar type

What is Gastric Foveolar-type Adenoma? (Definition/Background Information)

• Gastric Foveolar-type Adenoma is a polyp arising in the stomach consisting of neoplastic foveolar epithelium
• It can be classified as low-grade dysplastic foveolar adenoma or high-grade dysplastic foveolar adenoma; high-grade dysplasia is typically rare within these polyps
• Most of these polyps are asymptomatic and detected incidentally on an endoscopy

Incidence:

• Most cases are diagnosed in adults
• Both males and females are affected

Risk factors:

• Familial adenomatous polyposis (FAP) syndrome
• Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) syndrome

Cause:

• The exact cause of formation of Gastric Foveolar-type Adenoma is currently unknown
• It may be associated with certain genetic mutations
• Sporadic Foveolar-type Adenomas of Stomach are uncommon. Most of these polyps are noted in syndromes (syndromic Foveolar-type Adenoma of Stomach)

Signs and symptoms:

• A vast majority of these polyps are asymptomatic and cause no signs and symptoms
• Signs and symptoms of the underlying syndrome (if any) may be noted

Diagnosis:

• The polyps may be diagnosed via an endoscopy
• Tissue biopsy of the polypoid mass can help achieve a definitive diagnosis

Complications: Complications may arise from the associated genetic syndromes and high-grade dysplasia.

Treatment:

• A complete surgical excision of Gastric Foveolar-type Adenoma results in a cure
• Close clinical follow-up with periodic endoscopic examinations may be recommended, typically if high-grade dysplastic changes are observed

Prevention: Presently, it is not possible to prevent the formation of Gastric Foveolar-type Adenomas.

Prognosis:

• The prognosis is usually excellent, especially if the tumors are solitary and show no areas of high-grade dysplasia
• If high-grade dysplasia is noted in individuals that have certain syndromes as risk factors, then close clinical follow-up is recommended through periodic endoscopic examination