What are the other Names for this Condition? (Also known as/Synonyms)

• Gigantiform Cementoma

What is Florid Cemento-Osseous Dysplasia? (Definition/Background Information)

• Florid Cemento-Osseous Dysplasia is characterized by lesions in the upper and/or lower jaw that occur when normal bone is replaced with a mix of connective tissue and abnormal bone
• It tends to affect middle aged women, particularly women of African American and Asian descent
• The lesions often affect both sides of the jaw and are symmetrical. The number, size, and shape of the lesions vary. Occasionally the lesions expand and may cause discomfort, pain, or mild disfigurement. The radiographic appearance of the lesions are important for diagnosis

(Source: Florid Cemento-Osseous Dysplasia; Genetic and Rare Diseases Information Center (GARD) of National Center for Advancing Translational Sciences (NCATS), USA.)

Who gets Florid Cemento-Osseous Dysplasia? (Age and Sex Distribution)

• Florid Cemento-Osseous Dysplasia is a rare disorder affecting middle aged women 
• Worldwide, individuals of all racial and ethnic groups may be affected. However, the condition is more common in Asian and African-American women

What are the Risk Factors for Florid Cemento-Osseous Dysplasia? (Predisposing Factors)

• A positive family history may be an important risk factor, since Florid Cemento-Osseous Dysplasia can be inherited in rare cases
• Being a woman of African-American or Asian descent is a known risk factor for this disorder

It is important to note that having a risk factor does not mean that one will get the condition. A risk factor increases one’s chances of getting a condition compared to an individual without the risk factors. Some risk factors are more important than others.

Also, not having a risk factor does not mean that an individual will not get the condition. It is always important to discuss the effect of risk factors with your healthcare provider.

What are the Causes of Florid Cemento-Osseous Dysplasia? (Etiology)

The cause of Florid Cemento-Osseous Dysplasia is not known.

• This condition is usually not familial (i.e., does not tend to run in families), however a rare familial form has been described in a few families
• In these families the condition affected younger individuals, and the rate of lesion growth was rapid

(Source: Florid Cemento-Osseous Dysplasia; Genetic and Rare Diseases Information Center (GARD) of National Center for Advancing Translational Sciences (NCATS), USA.)

What are the Signs and Symptoms of Florid Cemento-Osseous Dysplasia?

The signs and symptoms of Florid Cemento-Osseous Dysplasia may include:

• Cementoma
• Misalignment of teeth
• Multiple impacted teeth

(Source: Florid Cemento-Osseous Dysplasia; Genetic and Rare Diseases Information Center (GARD) of National Center for Advancing Translational Sciences (NCATS), USA.)

How is Florid Cemento-Osseous Dysplasia Diagnosed?

• Diagnosis of Florid Cemento-Osseous Dysplasia relies on the radiographic findings of the lesions as well as the clinical signs and symptoms
• Careful assessment and examination must be made to differentiate cemento-osseous dysplasia from other lesions with similar appearance, namely Paget's disease, chronic diffuse sclerosing osteomyelitis, fibrous dysplasia, osteosarcoma, periapical cemental dysplasia

(Source: Florid Cemento-Osseous Dysplasia; Genetic and Rare Diseases Information Center (GARD) of National Center for Advancing Translational Sciences (NCATS), USA.)

Many clinical conditions may have similar signs and symptoms. Your healthcare provider may perform additional tests to rule out other clinical conditions to arrive at a definitive diagnosis.

What are the possible Complications of Florid Cemento-Osseous Dysplasia?

The complications of Florid Cemento-Osseous Dysplasia may include:

• Severe pain
• Disfigurement leading to low self-esteem

Complications may occur with or without treatment, and in some cases, due to treatment also.

How is Florid Cemento-Osseous Dysplasia Treated?

• In many cases Florid Cemento-Osseous Dysplasia does not require treatment, however careful follow-up may be warranted
• When the condition causes discomfort, pain, or disfigurement, the treatment plan is tailored to the patient

(Source: Florid Cemento-Osseous Dysplasia; Genetic and Rare Diseases Information Center (GARD) of National Center for Advancing Translational Sciences (NCATS), USA.)

How can Florid Cemento-Osseous Dysplasia be Prevented?

At the present time, no preventive methods or guidelines are available for Florid Cemento-Osseous Dysplasia, since the cause is not known in most cases.

• If there is a family history of the condition, then genetic counseling will help assess risks, before planning for a child
• Active research is currently being performed to explore the possibilities for treatment and prevention of disorders such as Florid Cemento-Osseous Dysplasia

Regular medical and dental screening at periodic intervals with tests and physical examinations are recommended.

What is the Prognosis of Florid Cemento-Osseous Dysplasia? (Outcomes/Resolutions)

• The prognosis of Florid Cemento-Osseous Dysplasia is dependent upon the severity of the signs and symptoms and associated complications, if any
• Individuals with mild conditions have better prognosis than those with severe symptoms and complications
• In general, the prognosis is good

Additional and Relevant Useful Information for Florid Cemento-Osseous Dysplasia:

The following DoveMed website link is a useful resource for additional information:

http://www.dovemed.com/diseases-conditions/rare-disorders/