What are the other Names for this Condition? (Also known as/Synonyms)

• Chromosome 15 Disorders

What are Disorders of Chromosome 15? (Definition/Background Information)

There are many disorders that are caused by abnormalities on chromosomes 15. Some are more common than others. Researchers know more about certain chromosomal disorders than others. Information is constantly being added through research, better documentation, and increased awareness.

Chromosomes are microscopic protein structures present in each cell nucleus that carry genetic information in the form of DNA (deoxyribonucleic acid). Humans have 46 chromosomes in the cell nucleus, in 23 pairs, of which one pair is named the sex chromosome. In males, it is designated XY, for chromosome X and chromosome Y; while, in females, it is designated XX, for a pair of chromosome X. The other 22 pairs of chromosomes are numbered chromosome 1 through 22.

During conception, the embryo inherits one copy of each chromosome from each parent (i.e., mother and father). Any alteration in the chromosome numbers or structure can result in mild to severe genetic abnormalities. Specialized genetic testing techniques are often required to confirm the diagnosis.

Chromosome 15 Disorders are disorders involving chromosome 15. Some of the disorders include:

Chromosome 15q Deletion Syndrome: Chromosome 15q Deletion Syndrome is a genetic disorder characterized by the deletion of a portion of the long arm of chromosome 15. This syndrome can be associated with congenital heart defects. Common symptoms may include intellectual disability, developmental delays, behavioral challenges, distinctive facial features, and other systemic issues. Treatment involves managing the specific symptoms and providing supportive care through therapies and interventions tailored to the individual's needs.

Chromosome 15q Duplication Syndrome: Chromosome 15q Duplication Syndrome is a genetic condition characterized by the presence of an extra copy of a portion of the long arm of chromosome 15. While congenital heart defects are not commonly associated with this syndrome, individuals may experience intellectual disability, developmental delays, behavioral challenges, distinctive facial features, and other variable symptoms. Treatment primarily focuses on managing the specific symptoms and providing supportive care through therapies and interventions tailored to the individual's needs.

Chromosome 15q11.2 Microdeletion Syndrome: Chromosome 15q11.2 Microdeletion Syndrome is a rare genetic disorder characterized by the deletion of a small region within chromosome 15q11.2. While congenital heart defects are not typically associated with this syndrome, individuals may experience intellectual disability, developmental delays, behavioral challenges, distinctive facial features, and other variable symptoms. Treatment involves managing the specific symptoms and providing supportive care through therapies and interventions tailored to the individual's needs.

Chromosome 15q11.2 Microduplication Syndrome: Chromosome 15q11.2 Microduplication Syndrome is a rare genetic condition characterized by the duplication of a small region within chromosome 15q11.2. While congenital heart defects are not commonly associated with this syndrome, individuals may experience intellectual disability, developmental delays, behavioral challenges, distinctive facial features, and other variable symptoms. Treatment focuses on managing the specific symptoms and providing supportive care through therapies and interventions tailored to the individual's needs.

Chromosome 15q11q13 Duplication Syndrome: Chromosome 15q11q13 Duplication Syndrome is a rare genetic disorder characterized by the duplication of genetic material in the long arm of chromosome 15, specifically within the 15q11q13 region. While congenital heart defects are not commonly associated with this syndrome, individuals may experience intellectual disability, developmental delays, behavioral challenges, distinctive facial features, and other variable symptoms. Treatment primarily focuses on managing the specific symptoms and providing supportive care through therapies and interventions tailored to the individual's needs.

Chromosome 15q13.3 Microdeletion Syndrome: Chromosome 15q13.3 Microdeletion Syndrome is a rare genetic disorder caused by the deletion of a small region within chromosome 15q13.3. While congenital heart defects are not typically associated with this syndrome, individuals may experience intellectual disability, developmental delays, behavioral challenges, distinctive facial features, and other variable symptoms. Treatment involves managing the specific symptoms and providing supportive care through therapies and interventions tailored to the individual's needs.

Chromosome 15q13.3 Microduplication Syndrome: Chromosome 15q13.3 Microduplication Syndrome is a rare genetic condition characterized by the duplication of a small region within chromosome 15q13.3. While congenital heart defects are not commonly associated with this syndrome, individuals may experience intellectual disability, developmental delays, behavioral challenges, distinctive facial features, and other variable symptoms. Treatment focuses on managing the specific symptoms and providing supportive care through therapies and interventions tailored to the individual's needs.

Chromosome 15q14 Deletion Syndrome: Chromosome 15q14 Deletion Syndrome is a rare genetic disorder caused by the deletion of a portion of the long arm of chromosome 15 within the 15q14 region. While congenital heart defects can occur in individuals with this syndrome, symptoms may vary widely. Common features include intellectual disability, developmental delays, behavioral challenges, distinctive facial features, and other systemic issues. Treatment involves managing the specific symptoms and providing supportive care through therapies and interventions to optimize the individual's overall well-being.

Chromosome 15q24 Microdeletion Syndrome: Chromosome 15q24 Microdeletion Syndrome is a rare genetic disorder characterized by the deletion of a small region within chromosome 15q24. While congenital heart defects are not commonly associated with this syndrome, individuals may experience intellectual disability, developmental delays, distinctive facial features, growth abnormalities, and other variable symptoms. Treatment focuses on managing the specific symptoms and providing supportive care through therapies and interventions tailored to the individual's needs.

Chromosome 15q25.2 Microdeletion Syndrome: Chromosome 15q25.2 Microdeletion Syndrome is a rare genetic disorder caused by the deletion of a small region within chromosome 15q25.2. While congenital heart defects are not typically associated with this syndrome, individuals may experience intellectual disability, developmental delays, behavioral challenges, distinctive facial features, and other variable symptoms. Treatment involves managing the specific symptoms and providing supportive care through therapies and interventions tailored to the individual's needs.

Chromosome 15q26 Deletion Syndrome: Chromosome 15q26 Deletion Syndrome is a rare genetic disorder caused by the deletion of a portion of the long arm of chromosome 15 within the 15q26 region. While congenital heart defects can occur in individuals with this syndrome, symptoms may vary widely. Common features include intellectual disability, developmental delays, behavioral challenges, distinctive facial features, and other systemic issues. Treatment involves managing the specific symptoms and providing supportive care through therapies and interventions to optimize the individual's overall well-being.

Isodicentric Chromosome 15 Syndrome: Isodicentric Chromosome 15 Syndrome, also known as Idic(15) or Inverted Duplication 15 Syndrome, is a rare genetic disorder characterized by the presence of an extra piece of chromosome 15 that is duplicated and inverted. This syndrome is commonly associated with congenital heart defects. Other features may include intellectual disability, developmental delays, seizures, distinctive facial features, and behavioral issues. Treatment focuses on managing the specific symptoms, addressing any associated health concerns, and providing supportive care through therapies and interventions tailored to the individual's needs.

Ring Chromosome 15 Syndrome: Ring Chromosome 15 Syndrome is a rare chromosomal disorder where the genetic material of chromosome 15 forms a ring structure. Congenital heart defects can occur in individuals with this syndrome, along with other features such as intellectual disability, developmental delays, distinctive facial features, growth abnormalities, and other systemic issues. Treatment involves managing the specific symptoms and providing supportive care through therapies and interventions to optimize the individual's overall well-being.

This article is a resource with links to other more specific disorders. Information on each Chromosome 15 Disorder may be viewed by clicking on the respective subtypes (above).

Information to join DoveMed’s patient forum called MyCIrcles to learn and manage the condition is also included. We are adding more information to this page periodically. Please bookmark this page for future reference and visit for updated content.

You can join Chromosome Disorders MyCircles patient forum by visiting here: https://www.dovemed.com/mycircles/circles/all