What are the other Names for this Condition? (Also known as/Synonyms)

• Clear Cell Urothelial Carcinoma (CCUC)
• Glycogen-Rich, Clear Cell Variant of Urothelial Carcinoma
• Urothelial Carcinoma with Clear Cytoplasm (Glycogen-Rich)

What is Clear Cell (Glycogen-Rich) Urothelial Carcinoma? (Definition/Background Information)

• Clear Cell (Glycogen-Rich) Urothelial Carcinoma is an extremely rare and aggressive subtype of invasive urothelial carcinoma (UCC), a form of malignancy of the urothelium (urothelial cells that line the urothelial tract). It is also known as Clear Cell Urothelial Carcinoma (CCUC)
• Glycogen-Rich, Clear Cell Variant of Urothelial Carcinoma is diagnosed under the microscope, on examination of the cancer cells by a pathologist. The tumor is characterized by rapid progression and aggressive clinical course. It should be differentiated from clear cell adenocarcinoma of the urinary tract. The classification of the tumor is important, as it may dictate the type of treatments to be provided and the overall outcomes
• The exact cause of Clear Cell (Glycogen-Rich) Urothelial Carcinoma is presently unknown. The condition is noted in middle-aged and older adults, mostly in men. Many contributory factors, such as smoking (a significant risk factor), occupational exposure to chemicals, and prior radiation therapy, are noted
• The signs and symptoms of Clear Cell (Glycogen-Rich) Urothelial Carcinoma usually include blood in urine (hematuria), burning sensation on urination, and back pain. The tumor is mostly diagnosed during the later stages, presenting muscle invasion and metastasis to the lymph nodes and other organs
• The treatment may include surgery, chemotherapy, and radiation therapy based on the healthcare provider’s assessment. Individuals with Clear Cell (Glycogen-Rich) Urothelial Carcinoma typically have poor prognoses; the outcomes are much worse than conventional urothelial carcinomas with which it may coexist