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Ahumada-Del Castillo syndrome is an endocrine disorder that results in the lack of function of pituitary and hypothalamus glands in women.

What are the other Names for this Condition? (Also known as/Synonyms)

  • Argonz-Del Castillo Syndrome
  • Argonz-Ahumada-Del Castillo Syndrome
  • Nonpuerperal Galactorrhea-Amenorrhea

What is Ahumada-Del Castillo Syndrome? (Definition/Background Information)

  • Ahumada-Del Castillo syndrome is an endocrine disorder that results in the lack of function of pituitary and hypothalamus glands in women.
  • Typically, the syndrome causes symptoms that make it appear that the woman is pregnant even when she is not carrying a child. 

Who gets Ahumada-Del Castillo Syndrome? (Age and Sex Distribution)

  • Females are the only ones that are affected by Ahumada-Del Castillo syndrome.
  • The syndrome most often affects adult females. 

What are the Risk Factors for Ahumada-Del Castillo Syndrome? (Predisposing Factors) 

Common risk factors of Ahumada-Del Castillo syndrome include:

  • Tumors in the pituitary gland
  • Tumors in the hypothalamus gland
  • Low thyroid levels
  • Chronic drug use

It is important to note that having a risk factor does not mean that one will get the condition. A risk factor increases ones chances of getting a condition compared to an individual without the risk factors. Some risk factors are more important than others.

Also, not having a risk factor does not mean that an individual will not get the condition. It is always important to discuss the effect of risk factors with your healthcare provider.

What are the Causes of Ahumada-Del Castillo Syndrome? (Etiology)

  • Ahumada-Del Castillo syndrome is caused by compression of the pituitary stalk. When this occurs, the pituitary gland is unable to function properly due to its compromised state.
  • This syndrome can also result from reduced dopamine levels, which often causes the body to produce abnormal levels of various chemicals that can be seen in the symptoms of the disorder.
  • Ahumada-Del Castillo syndrome can also be caused by tumors in the pituitary gland or hypothalamus gland. When tumors are present in these glands, it makes it more difficult for them to function properly. If proper functioning does not occur, the body will be out of balance and result in symptoms common to the syndrome. 

What are the Signs and Symptoms of Ahumada-Del Castillo Syndrome?

Common signs and symptoms of Ahumada-Del Castillo syndrome include:

  • Estrogen deficiency
  • Low urine excretion
  • Lactation in the absence of breastfeeding (production of breast milk)
  • Amenorrhea (lack of menstrual periods)
  • Lack of egg production by ovaries

How is Ahumada-Del Castillo Syndrome Diagnosed?

  •  A medical professional will perform a physical examination to diagnose Ahumada-Del Castillo syndrome
  • Afterwards, a variety of laboratory tests, including blood tests and thyroid examinations will be done to confirm the diagnosis.
  • To ensure that the condition is not misdiagnosed, chlamydia, hepatitis, and herpes tests are often conducted.

Many clinical conditions may have similar signs and symptoms. Your healthcare provider may perform additional tests to rule out other clinical conditions to arrive at a definitive diagnosis.

What are the possible Complications of Ahumada-Del Castillo Syndrome?

  • It is possible that complications will arise from Ahumada-Del Castillo syndrome. These complications can include:
    • Low hormone levels (most commonly follicle stimulating hormone)
    • Abnormal breast milk production
    • Prolonged lack of menstrual periods

How is Ahumada-Del Castillo Syndrome Treated?

  • To treat Ahumada-Del Castillo syndrome, a variety of medications are prescribed to help stimulate the production of dopamine. These medications commonly include perogolide and bromocriptine.
  • Surgical removal of pituitary gland and hypothalamus gland tumors is also done to treat Ahumada-Del Castillo syndrome.
  • In cases where surgical removal is not possible, radiation therapy is recommended to treat the tumor. 

How can Ahumada-Del Castillo Syndrome be Prevented? 

  • Currently, no prevention methods for Ahumada-Del Castillo syndrome are known.

What is the Prognosis of Ahumada-Del Castillo Syndrome? (Outcomes/Resolutions)

  • With proper treatment, most individuals with Ahumada-Del Castillo syndrome are able to stop extra breast milk production and return to their normal schedule of menstrual periods.
  • Most females are able to return to normal lives before the syndrome began.

Additional and Relevant Useful Information for Ahumada-Del Castillo Syndrome:

The following DoveMed website link is a useful resource for additional information:


What are some Useful Resources for Additional Information?

National Women's Health Resource Center
157 Broad Street, Suite 106 Red Bank, NJ 07701
Phone: (732) 530-3425
Toll-Free: (877) 986-9472
Fax: (732) 530-3347
Email: gcassidy@healthywomen.org
Website: http://www.healthywomen.org

National Women's Health Network
1413 K Street, NW 4th Floor Washington, D.C. 20005 USA
Phone: (202) 682-2640
Fax: (202) 682-2648
Email: nwhn@nwhn.org
Website: http://www.womenshealthnetwork.org

RESOLVE: National Infertility Association
1760 Old Meadow Rd Suite 500 McLean, VA 22102
Phone: (703) 556-7172
Fax: (703) 506-3266
Email: info@resolve.org
Website: http://www.resolve.org

The American Fertility Association (AFA)
315 Madison Avenue Suite 901 New York, NY 10017
Phone: (888) 917-3777
Email: Info@TheAFA.org
Website: http://www.theafa.org

References and Information Sources used for the Article:

http://www.britannica.com/EBchecked/topic/10316/Ahumada-del-Castillo-syndrome (accessed on September 9, 2013)

https://icmmt.alere.com/kbase/nord/nord155.htm (accessed on September 9, 2013)

http://checkorphan.com/disease/ahumada-del-castillo-syndrome (accessed on September 9, 2013)

Helpful Peer-Reviewed Medical Articles:

Spellacy, W. N., Carlson, K. L., & Schade, S. L. (1968). Human growth hormone studies in patients with galactorrhea (Ahumada-del Castillo syndrome). American journal of obstetrics and gynecology, 100(1), 84-89.

Nyirjesy, I. (1968). Ovarian morphology in amenorrhea-galactorrhea syndromes. American Journal of Obstetrics & Gynecology, 101(4), 458-461.

Buxton, C. L., & Herrmann, W. (1961). INDUCTION OF OVULATION IN THE HUMAN WITH HUMAN GONADOTROPINS: PRELIMINARY REPORT. Obstetrical & Gynecological Survey, 16(4), 530-531.

PENDE, T. (1959). Pathogenetic considerations on a case of galactorrhea with amenorrhea (Chiari-Frommel syndrome or Ahumada-Del Castillo syndrome. Endocrinologia e scienza della costituzione, 25, 419.

Sachdev, S., Sachdev, J. C., & Bhasin, R. C. (1973). Idiopathic galactorrhea with massive hypertrophy of breasts (a variant of Ahumada Del-Castillo syndrome). The Journal of the Association of Physicians of India, 21(5), 461-463.

Ariza, M. Á. A. (2005). Medical English: a short study of Spanish borrowings. Lebende Sprachen, 50(2), 58-61.

Alcaraz Ariza, M. Á. (2012). The English of the health sciences: a note on foreign borrowings. Pituitary, H. Reference Preparations.

Littrup, P. J., Freeman-Gibb, L., & Andea, A. (2017). BREAST INTRADUCTAL PAPILLOMA. Netter's Obstetrics and Gynecology E-Book, 20, 167.