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New Formula Can Predict Professional Football Players' Long-Term Concussion Damages

Last updated March 10, 2016

Approved by: Maulik P. Purohit MD MPH

Photo by University of the Fraser Valley

"The most important factor in determining the potential cognitive deficits from sports-related concussions was the football players' cognitive reserv."


Amid the heightened awareness of concussion-related brain damage among professional football players, a new study reports that researchers can predict cognitive outcomes long after the players have retired by reviewing the players' concussion histories, game-related data and their overall mental abilities.

Researchers studied the severity and frequency of game-related concussions among 40 former professional football players, many of whom had suffered cognitive deficits. The researchers combined this data with the estimates of each player's cognitive reserve, a mechanism which helps protect the brain from injury.

Cognitive reserve is developed through mentally enriching experiences, such as education and reading. The researchers concluded that a unique combination of the harmful and the protective factors can predict cognitive outcomes in players who had suffered concussions during their football careers and have been retired from American professional football for an average of 20 years.

"The most important factor in determining the potential cognitive deficits from sports-related concussions was the football players' cognitive reserve" said Matthew J. Wright, PhD, an LA BioMed lead researcher and lead author of the paper published online in the Journal of Clinical and Experimental Psychology. "We also found that post-traumatic amnesia after a concussion was a more significant predictor of later cognitive deficits than the loss of consciousness."

The research was conducted at LA BioMed, the John Wayne Cancer Institute and the University of North Carolina at Chapel Hill. To determine cognitive reserve, the researchers utilized test, questionnaire and interview data. The researchers also surveyed other studies, which have found cognitive reserve is protective in other forms of brain injury and disease, including Alzheimer's disease.

The study's findings are significant because, after motor vehicle accidents, sports-related injuries are the second-most common cause of traumatic brain injuries. Sports-related injuries account for as many as 3.8 million traumatic brain injuries per year in the U.S., according to researchers. Young men, aged 10-19 years, tend to have the highest rates of sports concussions, and 5% to 10% of high school and college American football players are at risk of suffering a concussion each year.

"While further study is needed, our findings open the door to the possibility that professional football could use individual indices to predict the potential for long-term cognitive losses in determining when, or if, a player should return to the field after suffering a concussion," Dr. Wright said.



The above post is reprinted from materials provided by Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed)Note: Materials may be edited for content and length.

Disclaimer: DoveMed is not responsible for the adapted accuracy of news releases posted to DoveMed by contributing universities and institutions.

Primary Resource:

Wright, M. J., Woo, E., Birath, J. B., Siders, C. A., Kelly, D. F., Wang, C., ... & Guskiewicz, K. (2016). An index predictive of cognitive outcome in retired professional American Football players with a history of sports concussion. Journal of Clinical and Experimental Neuropsychology, 1-11.

Reviewed and Approved by a member of the DoveMed Editorial Board
First uploaded: March 10, 2016
Last updated: March 10, 2016