Mayo Clinic researchers have found that engaging in mentally stimulating activities, even late in life, may protect against new-onset mild cognitive impairment, which is the intermediate stage between normal cognitive aging and dementia. The study found that cognitively normal people 70 or older who engaged in computer use, craft activities, social activities and playing games had a decreased risk of developing mild cognitive impairment. The results are published in the Jan. 30 edition of JAMA Neurology.

Researchers followed 1,929 cognitively normal participants of the population-based Mayo Clinic Study of Aging in Olmsted County, Minn., for an average duration of four years. After adjusting for sex, age and educational level, researchers discovered that the risk of new-onset mild cognitive impairment decreased by 30 percent with computer use, 28 percent with craft activities, 23 percent with social activities, and 22 percent with playing games.

"Our team found that persons who performed these activities at least one to two times per week had less cognitive decline than those who engaged in the same activities only two to three times per month or less," says Yonas Geda, M.D., psychiatrist and behavioral neurologist at Mayo Clinic's Arizona campus and senior author of the study.

Researchers conducted a neurocognitive assessment at the time of enrollment in the study, with evaluations every 15 months. Following the assessment, an expert consensus panel at the Alzheimer Disease Research Center at Mayo Clinic made the classification of normal cognition or mild cognitive impairment for each study participant, based on published criteria.

"Our previous cross-sectional study had found an association between engagement in mentally stimulating activities in late life and decreased odds of mild cognitive impairment," says Dr. Geda. "However, those findings were considered preliminary until confirmed by a prospective cohort study that we are now reporting in JAMA Neurology."

The benefits of being cognitively engaged even were seen among apolipoprotein E (APOE) ?4 carriers. APOE ?4 is a genetic risk factor for mild cognitive impairment and Alzheimer's dementia. However, for APOE ?4 carriers, only computer use and social activities were associated with a decreased risk of mild cognitive impairment.

"Even for a person who is at genetic risk for cognitive decline, engaging in some activities was beneficial," says Janina Krell-Roesch, Ph.D., the first author of the study and a postdoctoral researcher in Dr. Geda's Translational Neuroscience and Aging Program (TAP). "So I think the signal is there even for APOE ?4 carriers."

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Primary Resource:

Krell-Roesch, J., Vemuri, P., Pink, A., Roberts, R. O., Stokin, G. B., Mielke, M. M., ... & Geda, Y. E. (2017). Association Between Mentally Stimulating Activities in Late Life and the Outcome of Incident Mild Cognitive Impairment, With an Analysis of the APOE ε4 Genotype. JAMA neurology. DOI: 10.1001/jamaneurol.2016.3822