The primary JAK2 Mutation Analysis determines a point mutation, called JAK2 V617F. Nine of ten individuals with polycythemia vera have JAK2 mutation. Only half of the individuals diagnosed with essential thrombocythemia and/or primary myelofibrosis are positive for JAK2 mutation. There are other mutations in the JAK2 gene, in exons 12 and also in exons 13, which are distinct from JAK2 V617F.
When a physician suspects a myeloproliferative disorder, a JAK2 Mutational Analysis is performed. The signs and symptoms of a myeloproliferative disorder include:
Sample required: Blood
Process: A sample of blood is drawn using a syringe inserted into a superficial vein of the arm.
Preparation required: No special preparation is required.
JAK2 Mutational Analysis is helpful in providing information in both treatment and prognosis of a myeloproliferative disorder. However, it is important to note that the main value of performing a JAK2 Mutation Test is in the diagnosis and not prognosis, of a myeloproliferative disorder.
The laboratory test results are NOT to be interpreted as results of a "stand-alone" test. The test results have to be interpreted after correlating with suitable clinical findings and additional supplemental tests/information. Your healthcare providers will explain the meaning of your tests results, based on the overall clinical scenario.
Certain medications that you may be currently taking may influence the outcome of the test. Hence, it is important to inform your healthcare provider, the complete list of medications (including any herbal supplements) you are currently taking. This will help the healthcare provider interpret your test results more accurately and avoid unnecessary chances of a misdiagnosis.
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