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Herpes Blood Test

Last updated May 9, 2019

Approved by: Maulik P. Purohit MD, MPH


Microscopic pathology image showing Herpes infection.

What are the other Names for this Test? (Equivalent Terms)

  • Herpes Blood Culture Test
  • HHV-1 Blood Test
  • HSV DNA Blood Test

What is Herpes Blood Test? (Background Information)

  • Herpes viruses are a large group of viruses, many of which cause human illnesses
  • Herpes simplex 1 virus (HSV-1) primarily infects the oral cavity and mouth, causing blisters and cold sores. HSV-1 is mainly spread through the saliva
  • Herpes simplex 2 virus (HSV-2) primarily infects the region around the genitals and anus, causing painful blisters. HSV-2 is mainly spread through sexual contact
  • HSV-1 is also known to infect the region around the genitals and anus, as HSV-2 is known to infect the oral cavity and mouth. Herpes virus can also be transmitted to a newborn during delivery
  • Herpes virus causes symptoms within 3-5 days; some symptoms may persist for 2-3 weeks. They may be so mild, so as to go unnoticed
  • After this time, the virus enters a period of dormancy, called the latent phase. The virus may emerge during times of immunosuppression, such as illness and stress
  • There are no known cures for herpes virus infections. However, antiviral drugs are sometimes used to shorten the active phase, or the period of time during which the virus “sheds”. This (virus “sheds”) means the time of infection during which the herpes virus is actively multiplying in the body and is released into various body fluids. During the active shedding period, the virus may be transmitted or spread from one person to another
  • After infection by herpes virus, the immune system creates antibodies specific to it. Antibodies are proteins that recognize foreign objects, such as herpes, and help rid them from the body. The presence of antibodies against herpes virus in the bloodstream is indicative of a prior exposure to herpes virus. This is diagnostic of a current or past infection

The Herpes Test detects the presence of herpes virus in a sample of body fluid, using one of several methods. These include:

  • Culturing: The specimen is used to infect test cells, which can be analyzed and further identified as either HSV-1 or HSV-2
  • Antibody testing: The specimen is analyzed for antibodies against herpes virus. These include short-term IgM antibodies and long-term IgG antibodies, which continue to be produced for the rest of an individual’s life
  • DNA testing: The specimen is analyzed for the presence of herpes virus DNA. The virus can further be identified as either HSV-1 or HSV-2. This test is more sensitive than other tests

The Herpes Blood Test uses blood as a sample for testing and analysis. 

What are the Clinical Indications for performing the Herpes Blood Test?

Following are the clinical indicators for performing a Herpes Blood Test:

  • Blistering around the mouth, anus, or genitals
  • Sexual contact with an individual known to be infected by HSV
  • Fever, headache
  • Swollen lymph nodes

How is the Specimen Collected for Herpes Blood Test?

Following is the specimen collection process for Herpes Blood Test:

Sample required: Blood

Process of obtaining blood sample in adults:

  • A band is wrapped around the arm, 3-4 inches above the collection site (superficial vein that lies within the elbow pit)
  • The site is cleaned with 70% alcohol in an outward spiral, away from the zone of needle insertion
  • The needle cap is removed and is held in line with the vein, pulling the skin tight
  • With a small and quick thrust, the vein is penetrated using the needle
  • The required amount of blood sample is collected, by pulling the plunger of the syringe out slowly
  • The wrap band is removed, gauze is placed on the collection site, and the needle is removed
  • The blood is immediately transferred into the blood container, which has the appropriate preservative/clot activator/anti-coagulant
  • The syringe and the needle are disposed into the appropriate “sharp container” for safe and hygienic disposal

Preparation required: No special preparation is needed prior to the test.  

What is the Significance of the Herpes Blood Test Result?

The significance of Herpes Blood Test is explained:

  • A positive test may indicate an infection with HSV-1 or HSV-2
  • A negative test may indicate:
    • Not enough time has passed to allow for the production of detectable levels of anti-HSV antibodies
    • There may be an infection by a similar virus
    • The individual is incapable of producing anti-HSV antibodies and may be too young

The laboratory test results are NOT to be interpreted as results of a "stand-alone" test. The test results have to be interpreted after correlating with suitable clinical findings and additional supplemental tests/information. Your healthcare providers will explain the meaning of your tests results, based on the overall clinical scenario.

Additional and Relevant Useful Information:

  • Herpes virus usually causes a self-limiting disease; in other words, it resolves without the need for significant medical interventions. However, the symptoms may be alleviated through rest, consumption of fluids, and with proper medications
  • Herpes virus is a common infectious agent. An estimated 50% of US adults are infected with HSV-1 and 17% with HSV-2

Certain medications that you may be currently taking may influence the outcome of the test. Hence, it is important to inform your healthcare provider, the complete list of medications (including any herbal supplements) you are currently taking. This will help the healthcare provider interpret your test results more accurately and avoid unnecessary chances of a misdiagnosis.

References and Information Sources used for the Article:

Reviewed and Approved by a member of the DoveMed Editorial Board
First uploaded: May 4, 2015
Last updated: May 9, 2019