The topic Vaginal Squamous Cell Carcinoma, Non-Keratinizing Type you are seeking is a synonym, or alternative name, or is closely related to the medical condition Non-Keratinizing Squamous Cell Carcinoma of Vagina.

Quick Summary:

• Squamous Cell Carcinoma (SCC) of Vagina is a rare, malignant condition affecting the skin and mucosal membranes of the vagina, generally in middle-aged and older women. A vast majority of cancers arising from the vagina are squamous cell carcinomas
• Non-Keratinizing Squamous Cell Carcinoma of Vagina is the most common histological variant of Vaginal Squamous Cell Carcinoma. This differentiation is based on the appearance of cells when observed under a microscope by a pathologist
• This sub-classification of the tumor is important, as it may dictate the type of treatment to be provided and the prognosis of the cancer. Non-Keratinizing SCC of Vagina is associated with high-risk human papilloma virus (HPV) types
• Almost all vaginal cancers are believed to originate from a premalignant lesion, known as high-grade vaginal intraepithelial neoplasia (VaIN). Its association with high-risk human papilloma virus (HPV) is responsible for a transformation to squamous cell carcinomas
• This malignant carcinoma, which may be present as a lesion on the vagina, has the potential to metastasize (spread), usually to the regional lymph nodes. Most tumors are known to form in the upper one-third portion of the vagina, nearer to the uterine cervix
• If the biopsy shows Non-Keratinizing Squamous Cell Carcinoma of Vagina; then, the tumor is staged (growth and spread of cancer is examined) and treatment options chosen, based on the staging and other factors. The treatment may involve a combination of surgery, chemotherapy, and radiation therapy
• The prognosis of Non-Keratinizing Type Squamous Cell Carcinoma of Vagina depends upon a set of several factors including the stage of the tumor, age of the individual, the size of the tumor, and many other factors. The prognosis of the non-keratinizing subtype is reported to be worse than the other subtypes of Vaginal SCCs

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