Serum Syndrome

Serum Syndrome

Article
Allergy
Vein & Vascular Health
+1
Contributed byMaulik P. Purohit MD MPHApr 03, 2018

The topic Serum Syndrome you are seeking is a synonym, or alternative name, or is closely related to the medical condition Serum Sickness.

Quick Summary:

  • Serum Sickness is an allergic reaction to the presence of foreign proteins in blood. It usually occurs after exposure to certain medications or antiserums, usually following treatments for snake bites, rabies, or tetanus
  • Serum, or plasma, is a clear component of blood. It does not contain blood cells, but is rich in antibodies, a type of protein. Antiserum is derived from the serum of a human or animal, which is immune to a specific infection or poison
  • It is administered to an individual to aid in the development of antibodies against the infection or component. Antiserum is typically administered as a form of passive immunization in which the body produces antibodies, in response to the administered serum
  • Serum Sickness can develop in any individual who receives a form of antiserum. It is most commonly seen in individuals injected with proteins to help prevent organ transplant rejection (antithymocyte globulin) and to treat immune disorders (rituximab)
  • Serum Sickness occurs when the body mistakes the protein present within the antiserum as being harmful or dangerous to the body, and its immune system attacks these introduced foreign proteins
  • Symptoms usually develop within 1-3 weeks after receiving the antiserum and are recognized by fever, swollen, joints, and a rash in most cases. A medical history, physical examination, and simple blood and urine tests are used to diagnose Serum Sickness
  • The standard treatment for Serum Sickness is with antihistamines and NSAIDs, which can help reduce symptoms
  • The prognosis of Serum Sickness is very good, and most individuals can expect a full recovery within a few weeks. While complications are generally uncommon, individuals may develop anaphylaxis, swelling of the face, and nerve inflammation
  • Serum Sickness cannot be prevented if the allergy remains unidentified. If there is a history of a specific allergy, then avoidance of the triggering antiserum, can help prevent Serum Sickness

Please find comprehensive information on Serum Sickness regarding definition, distribution, risk factors, causes, signs & symptoms, diagnosis, complications, treatment, prevention, prognosis, and additional useful information HERE.

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Maulik P. Purohit MD MPH picture
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Maulik P. Purohit MD MPH

Assistant Medical Director, Medical Editorial Board, DoveMed Team

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