Pilotropic Mycosis Fungoides

Pilotropic Mycosis Fungoides

Article
Skin Care
Diseases & Conditions
+2
Contributed byLester Fahrner, MD+1 moreJun 14, 2021

The topic Pilotropic Mycosis Fungoides you are seeking is a synonym, or alternative name, or is closely related to the medical condition Folliculotropic Mycosis Fungoides.

Quick Summary:

  • Folliculotropic Mycosis Fungoides is a rare variant of mycosis fungoides (MF), which is a cutaneous T-cell non-Hodgkin’s lymphoma. Here, the malignant lymphocytes involve the hair follicles, and hence, the name of the condition
  • It is a form of primary cutaneous non-Hodgkin lymphoma, meaning it is a lymphoma that is first seen in the skin. At a later stage, it can involve other parts of the body including the lymph nodes and bone marrow. This is known as systemic Folliculotropic Mycosis Fungoides
  • Folliculotropic Mycosis Fungoides can result in the formation of skin lesions (patches and plaques) that may ulcerate and cause subsequent infections. If other parts of the body are also affected, widespread symptoms, such as weight loss, fatigue, anemia, fever, and night sweats, can also be present
  • Folliculotropic Mycosis Fungoides is usually diagnosed with a biopsy of the affected skin or taking a biopsy of the swollen lymph nodes or affected organ. Other tests and procedures may be used to examine the severity and extent of the condition
  • Skin-directed therapy or systemic therapy may be used to treat Folliculotropic Mycosis Fungoides. However, it has been noted in some patients that the tumor does not respond to treatment
  • The prognosis depends on many elements including the progression of the condition, response to treatment, and health status of the individual. In general, the prognosis is poor, since this variant is more aggressive than classical Mycosis Fungoides

General information on lymphoma and lymphocytes:

  • Lymphoma is a form of cancer stemming from uncontrollable division of lymphocytes (type of white blood cells). There are two types of lymphomas:
    • Hodgkin lymphoma
    • Non-Hodgkin lymphoma
  • Lymphocytes are the primary white blood cells located in the lymph, which is the fluid of the lymphatic system; just as blood is the fluid of the circulatory system
  • Lymphocytes are produced in bone marrow, and can mature into either B-cells or T-cells. T-cells mature in the thymus; Folliculotropic Mycosis Fungoides arises from cancerous T-cells
  • Lymph results from filtration of blood as it moves to and from tissues. Lymph is colorless because it contains no red blood cells; instead, it contains lymphocytes. It is central to the immune system
  • There are 3 different kinds of lymphocytes:
    • T-lymphocytes or T cells: They help fight infections and irregularities within the cells (cell-mediated immunity). They fight viruses and cancerous cells
    • B-lymphocytes or B cells: They generate antibodies that are bodily defense proteins, which target foreign invaders outside the cells (humoral immunity). They combat bacterial cells, cell fragments, and other immunogenic elements
    • Natural killer cells or NK cells: They perform various functions related to both cell-mediated and humoral immunity. They also search for cancer cells, a process called immune surveillance

Please find comprehensive information on Folliculotropic Mycosis Fungoides regarding definition, distribution, risk factors, causes, signs & symptoms, diagnosis, complications, treatment, prevention, prognosis, and additional useful information HERE.

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On the Article

Krish Tangella MD, MBA picture
Approved by

Krish Tangella MD, MBA

Pathology, Medical Editorial Board, DoveMed Team
Lester Fahrner, MD picture
Reviewed by

Lester Fahrner, MD

Chief Medical Officer, DoveMed Team

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