Palmar-Plantar Erythrodysesthesia

Podiatry (Lower Leg & Foot)

Skin Care

Contributed byKrish Tangella MD, MBAOct 03, 2018

The topic Palmar-Plantar Erythrodysesthesia you are seeking is a synonym, or alternative name, or is closely related to the medical condition Hand-Foot Syndrome.

Quick Summary:

Hand-Foot Syndrome (HFS) is a painful skin condition that affects the palms and soles of individuals undergoing chemotherapy. HFS is probably caused due to the side effect of chemo-medication on skin tissue
A variety of chemotherapy medications have been implicated, which include 5-fluorouracil, methotrexate, EGFR tyrosine kinase inhibitors, cabozantinib, and regorafenib. Hand-Foot Syndrome is seen in both children and adults
The rashes in Hand-Foot Syndrome are painful. The condition can cause numbness in the affected skin region. The blisters may also ulcerate and peel. The lesions may slowly spread to involve the arms and legs too
The treatment measures for Hand-Foot Syndrome include stopping or discontinuing the use of such medications, along-with providing symptomatic treatment for the skin rashes
With adequate treatment (stoppage of the offending medication), Hand-Foot Syndrome may disappear. However, the condition usually recur on resumption of chemotherapy

Please find comprehensive information on Hand-Foot Syndrome regarding definition, distribution, risk factors, causes, signs & symptoms, diagnosis, complications, treatment, prevention, prognosis, and additional useful information HERE.

On the Article

Approved by

Krish Tangella MD, MBA

Pathology, Medical Editorial Board, DoveMed Team

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