The topic Ki-1 (CD30+) Lymphoma, Anaplastic Large Cell Lymphoma you are seeking is a synonym, or alternative name, or is closely related to the medical condition ALK-Positive Anaplastic Large Cell Lymphoma.

Quick Summary:

• Anaplastic Large Cell Lymphoma (ALCL) is an aggressive T-cell non-Hodgkin’s lymphoma. Based on its relation with the ALK gene, which is important for the production of the protein ALK, there are 2 main types of ALCL. These include:
  • ALK-Positive Anaplastic Large Cell Lymphoma: An ALK positive state is diagnosed when the ALK protein is present in the tumor cells
  • ALK-Negative Anaplastic Large Cell Lymphoma: An ALK negative state is diagnosed when the tumor cells lack the ALK protein
• ALK-Positive Anaplastic Large Cell Lymphoma can involve several parts of the body, such as the peripheral blood, lymph nodes, bone marrow, and organs, including the lung, liver, skin, and soft tissue. It is known to affect children and young adults
• Presently, no risk factors for ALK-Positive ALCL have been identified. However, the condition is associated with HIV infection and mycosis fungoides (in some cases). Also, the cause of development of this lymphoma remains under investigation
• The signs and symptoms of the condition may involve the whole body. It can include unexplained weight loss, weakness, night sweats, and frequent infections, apart from organ-specific clinical features
• A biopsy of the affected region may help establish a diagnosis of ALK-Positive ALCL. Various other diagnostic tests and exams may be undertaken to assess the extent of tumor spread and other parameters
• The treatment of ALK-Positive Anaplastic Large Cell Lymphoma may involve chemotherapy, radiation therapy, and surgery, depending upon the healthcare provider’s assessment of the condition
• The prognosis of ALK-Positive Anaplastic Large Cell Lymphoma depends on many factors including the stage of the tumor, involvement of various organs, and patient’s response to treatment. The prognosis is generally guarded

General information on lymphoma and lymphocytes:

• Lymphoma is a type of cancer stemming from uncontrollably dividing lymphocytes (type of white blood cells). There are two types of lymphomas:
  • Hodgkin lymphoma
  • Non-Hodgkin lymphoma
• Lymphocytes are the main white blood cells found in the lymph, which is the fluid of the lymphatic system; just as blood is the fluid of the circulatory system
• Lymphocytes are made in bone marrow, and can develop into either B-cells or T-cells. T-cells mature in the thymus; ALK-Positive Anaplastic Large Cell Lymphoma arises from cancerous T-cells
• Lymph results from filtration of blood as it travels to and from tissues. Lymph is colorless because it lacks red blood cells; instead, it contains lymphocytes. It is central to the immune system
• There are 3 different kinds of lymphocytes:
  • T-lymphocytes or T cells: They help combat infections and abnormalities within the cells (cell-mediated immunity). They fight viruses and cancerous cells
  • B-lymphocytes or B cells: They produce antibodies that are bodily defense proteins, which target foreign invaders outside the cells (humoral immunity). They fight bacterial cells, cell fragments, and other immunogenic elements
  • Natural killer cells or NK cells: They perform diverse functions related to both cell-mediated and humoral immunity. They also scout for cancer cells, a process called immune surveillance

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