Juvenile Pilocytic Astrocytoma

Juvenile Pilocytic Astrocytoma

Article
Brain & Nerve
Eye & Vision
+4
Contributed byKrish Tangella MD, MBADec 18, 2020

The topic Juvenile Pilocytic Astrocytoma you are seeking is a synonym, or alternative name, or is closely related to the medical condition Pilocytic Astrocytoma.

Quick Summary:

  • A Pilocytic Astrocytoma (PA) is a form of brain tumor. A brain tumor may be described as a mass of abnormally growing cells arising from the brain tissue (brain parenchyma and meninges) or the spinal cord (central spine). The brain along-with the spinal cord constitute the central nervous system (CNS) of the body
  • Broadly, brain tumors are classified as benign (non-cancerous) and malignant. Malignant tumors are cancerous and can spread or metastasize to other regions of the body. They generally exhibit rapid growth and, in some cases, may present symptoms during the early stages of development
  • The World Health Organization (WHO) classifies central nervous system tumors according to their grade and histological subtypes. A tumor subtype is determined by a pathologist after examining a tissue biopsy of the tumor under the microscope. This WHO classification system is used by healthcare professionals all over the world in diagnosing and treating these tumors
  • Pilocytic Astrocytoma is one of the most common central nervous system neoplasms diagnosed in childhood. Hence, the tumor is also known as Juvenile Pilocytic Astrocytoma (JPA). It is known to arise from several locations in the brain, including the cerebellum, thalamus, hypothalamus, brainstem, and the optic nerve. Per WHO, the tumor is part of a group designated “other astrocytic tumors”
  • Pilocytic Astrocytoma is a WHO grade I brain tumor, meaning that is designated as “low-grade”. Grade I tumors are the most benign of the tumors. They are slow-growing and are not known to infiltrate into the surrounding tissues. They offer a very high chance for surgery to be curative; and thus, have the best prognosis among all brain tumors with long-term survival being noted
  • The cause of formation of Pilocytic Astrocytomas are not well-established. It is reported that a combination of several factors may play a role in their formation, including genetic, environmental, and lifestyle-related. In some cases, the risk factors for tumor formation include the presence of certain familial genetic disorders such as neurofibromatosis type 1
  • In many individuals, Pilocytic Astrocytomas are slow-growing and small-sized tumors that cause no significant signs and symptoms. Larger tumors can cause signs and symptoms by compressing the adjacent brain tissue. Many tumors may remain asymptomatic and are detected incidentally during radiological imaging studies of the central nervous system, which are undertaken for other unrelated conditions
  • The signs and symptoms of Pilocytic Astrocytomas depend on the location of the tumor and may include headaches, weakness in arms or legs, and vision and speech problems. The tumor may also be associated with memory loss, personality changes, and seizures; complications may develop during/from the treatment too
  • The treatments for Pilocytic Astrocytoma may primarily involve surgery and radiation therapy; chemotherapy may be considered in some rare cases. The prognosis for individuals with Pilocytic Astrocytoma depend on a wide variety of factors, including the size and location of the tumor. The long-term overall prognosis is generally excellent in a majority, particularly with complete surgical resections

Please find comprehensive information on Pilocytic Astrocytoma regarding definition, distribution, risk factors, causes, signs & symptoms, diagnosis, complications, treatment, prevention, prognosis, and additional useful information HERE.

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Krish Tangella MD, MBA picture
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Krish Tangella MD, MBA

Pathology, Medical Editorial Board, DoveMed Team

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