Irido-Corneo-Trabecular Dysgenesis

Irido-Corneo-Trabecular Dysgenesis

Article
Eye & Vision
Diseases & Conditions
+1
Contributed byKrish Tangella MD, MBAApr 04, 2018

The topic Irido-Corneo-Trabecular Dysgenesis you are seeking is a synonym, or alternative name, or is closely related to the medical condition Peters Anomaly.

Quick Summary:

  • Peters Anomaly is a congenital condition that is characterized by corneal opacity (cloudiness of the cornea) resulting from anterior segment dysgenesis (ASD) during development. This means that the front portion of the eye does not develop normally, during fetal development of the eye (within the mother’s womb)
  • The exact cause of Peters Anomaly is believed to be a mutation in the FOXC1, PAX6, PITX2, CYP1B1, MAF, or MYOC genes. The risk factors may include having a family history of the disorder, premature birth, deficiency of heparan sulfate (an animal tissue polysaccharide), and fetal alcohol syndrome
  • The signs and symptoms of Peters Anomaly are associated with eyes and may include an opaque (cloudy) cornea, decreased vision, amblyopia, and microphthalmia. The complications may include corneal graft failure, infection, steroid-induced glaucoma, and many other conditions
  • A diagnosis of Peters Anomaly can be made through physical (eye) examinations and observations, along with genetic testing to establish the involved gene
  • Treatment measures for Peters Anomaly include corneal tissue replacement (keratoplasty), surgery with the intent to reduce or eliminate iridotrabecular contact, widening the anterior chamber angle (iridoplasty), or cataract extraction surgery
  • The prognosis of Peters Anomaly is generally poor in terms of eyesight as most individuals have a visual acuity of about 20/400 even after a corneal graft surgery

Please find comprehensive information on Peters Anomaly regarding definition, distribution, risk factors, causes, signs & symptoms, diagnosis, complications, treatment, prevention, prognosis, and additional useful information HERE.

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Krish Tangella MD, MBA

Pathology, Medical Editorial Board, DoveMed Team

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