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Idiopathic Aplastic Anemia

Aplastic anemia is a disorder that occurs due to bone marrow failure. Bone marrow is the soft, yellow (fatty) tissue located in the center of the bone.

The topic Idiopathic Aplastic Anemia you are seeking is a synonym, or alternative name, or is closely related to the medical condition Acquired Aplastic Anemia.

Quick Summary:

  • Aplastic anemia is a disorder that occurs due to bone marrow failure. Bone marrow is the soft, yellow (fatty) tissue located in the center of the bone
  • The blood cells are formed by stem cells located in the bone marrow. The 3 major types of blood cells are RBCs (red blood cells), WBCs (white blood cells), and platelets
  • In aplastic anemia, these stem cells are destroyed; due to which, the production of all the 3 blood cell types are affected, leading to a decreased count of blood cells (pancytopenia)

Aplastic anemia is broadly classified into Inherited Aplastic Anemia and Acquired Aplastic Anemia. Acquired Aplastic Anemia is a rare disorder:

  • In 75% of the cases, the cause is not identified, in which case it is known as Idiopathic Aplastic Anemia
  • In about 25% of the cases of Acquired Aplastic Anemia, the cause may be identified

Please find comprehensive information on Acquired Aplastic Anemia regarding definition, distribution, risk factors, causes, signs & symptoms, diagnosis, complications, treatment, prevention, prognosis, and additional useful information HERE.

What are some Useful Resources for Additional Information?

National Organization for Rare Disorders (NORD)
55 Kenosia Avenue Danbury, CT 06810
Phone: (203) 744-0100
Toll-Free: (800) 999-6673
Fax: (203) 798-2291        
Email: orphan@rarediseases.org
Website: http://www.rarediseases.org
Aplastic Anemia & MDS International Foundation, Inc.
100 Park Avenue, Suite 108, Rockville, MD 20850
Phone: (301) 279-7202
Toll-Free: (800) 747-2820
Fax: (301) 279-7205
Email: help@aamds.org
Website: http://www.aamds.org
Genetic and Rare Diseases (GARD) Information Center    
PO Box 8126 Gaithersburg, MD 20898-8126    
Toll-Free: (888) 205-2311
TTY: (888) 205-3223
International Telephone Access Number: (301) 251-4925    
Fax: (301) 251-4911        
Website: http://rarediseases.info.nih.gov

References and Information Sources used for the Article:

Nhlbi.nih.gov. What Causes Aplastic Anemia? - NHLBI, NIH. 2015. Available at: http://www.nhlbi.nih.gov/health/health-topics/topics/aplastic/causes. (accessed 06/14/2017)

Rarediseases.org. rare-diseases — National Organization for Rare Disorders. 2015. Available at: https://www.rarediseases.org/rare-disease-information/rare-diseases/byID/83/viewFullReport.  (accessed 06/14/2017)

Memorial Sloan Kettering Cancer Center. Pediatric Blood Disorders: Acquired Severe Aplastic Anemia. 2015. Available at: http://www.mskcc.org/pediatrics/childhood/pediatric-blood-disorders/acquired-severe-aplastic-anemia. (accessed 06/14/2017)

Helpful Peer-Reviewed Medical Articles:

Fouillard, L., Bensidhoum, M., Bories, D., Bonte, H., Lopez, M., Moseley, A. M., ... & Gourmelon, P. (2003). Engraftment of allogeneic mesenchymal stem cells in the bone marrow of a patient with severe idiopathic aplastic anemia improves stroma. Leukemia (08876924), 17(2).

Lior, B., & Yair, L. (2008). Idiopathic Aplastic Anemia. In Diagnostic Criteria in Autoimmune Diseases (pp. 519-523). Humana Press.

ROOT, J. H. (1930). Idiopathic Aplastic Anemia. New England Journal of Medicine, 203(25), 1225-1231.

Barr, L. C. (1932). Idiopathic aplastic anemia.

Cervenka, J., Arthur, D., & Yasis, C. (1981). Mitomycin C test for diagnostic differentiation of idiopathic aplastic anemia and Fanconi anemia. Pediatrics, 67(1), 119-127.