IDH Mutant and 1p/19q Codeleted Oligodendroglioma

IDH Mutant and 1p/19q Codeleted Oligodendroglioma

Article
Brain & Nerve
Diseases & Conditions
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Contributed byKrish Tangella MD, MBAJan 05, 2021

The topic IDH Mutant and 1p/19q Codeleted Oligodendroglioma you are seeking is a synonym, or alternative name, or is closely related to the medical condition Oligodendroglioma, IDH-Mutant and 1p/19q Codeleted type.

Quick Summary:

  • An oligodendroglioma (OD) is a type of brain tumor. A brain tumor may be described as a mass of abnormally growing cells arising from the brain tissue (brain parenchyma and meninges) or the spinal cord (central spine). The brain along-with the spinal cord constitute the central nervous system (CNS) of the body
  • Broadly, brain tumors are classified as benign (non-cancerous) and malignant. Malignant tumors are cancerous and can spread or metastasize to other regions of the body. They generally exhibit rapid growth and, in some cases, may present symptoms during the early stages of development
  • The World Health Organization (WHO) classifies central nervous system tumors according to their grade and histological subtypes. The diagnosis of a tumor subtype is made by the pathologist after examining a tissue biopsy of the tumor under a microscope. This WHO classification system is used by healthcare professionals all over the world in diagnosing and treating these tumors
  • Oligodendroglioma, IDH-Mutant and 1p/19q Codeleted type is a slow-growing brain tumor that arises from the glial cells (a type of brain cells). This slow-growing glioma (tumor of glial cells) can infiltrate diffusely into the surrounding brain tissue. By definition, the tumor has specific genetic mutations; it is characterized by mutations on either IDH1 or IDH2 genes with 1p/19q chromosomal codeletions. The tumor is commonly observed in young and middle-aged adults, arising from the cerebral hemispheres of the brain, particularly from the frontal lobes. Per WHO, the tumor forms a part of “diffuse astrocytic and oligodendroglial tumors”
  • IDH Mutant and 1p/19q Codeleted Oligodendrogliomas are categorized as WHO grade II and grade III brain tumors. The grade II tumors are low-grade, while grade III are high-grade tumors. Grade II tumors grow faster than grade I tumors; grade I tumors are the most benign of the brain tumors. Grade II tumors tend to be minimally infiltrative into the surrounding brain tissue but have the possibility to recur as a higher grade tumor following treatment. Grade III tumors are malignant and more infiltrative; they have a tendency to recur as a higher grade tumor following treatment
  • The cause of formation of Oligodendroglioma, IDH-Mutant and 1p/19q Codeleted type is not well-established. It is reported that a combination of several factors may play a role in their formation, including genetic, environmental, and lifestyle-related. The risk factors may include the presence of certain genetic disorders, exposure to ionized radiation, viral infections, and even head trauma
  • There is a gradual onset of signs and symptoms observed with Oligodendroglioma, IDH-Mutant and 1p/19q Codeleted type. This may also depend on the location of the tumor. Individuals may experience headaches, weakness in different parts of the body, seizures, vision and speech disturbances. Large-sized tumors may compress adjacent brain tissue resulting in complications
  • The treatment modalities for Oligodendroglioma, IDH Mutant and 1p/19q Codeleted may include surgery, radiation therapy, and chemotherapy. The prognosis is determined by a wide variety of factors, such as age of the individual, tumor size, and overall health status. The prognosis is generally favorable with early diagnosis and treatment, when compared to other similar tumor types

Please find comprehensive information on Oligodendroglioma, IDH-Mutant and 1p/19q Codeleted type regarding definition, distribution, risk factors, causes, signs & symptoms, diagnosis, complications, treatment, prevention, prognosis, and additional useful information HERE.

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Krish Tangella MD, MBA

Pathology, Medical Editorial Board, DoveMed Team

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