The topic Hypogammaglobulinemia you are seeking is a synonym, or alternative name, or is closely related to the medical condition Agammaglobulinemia.

Quick Summary:

• Agammaglobulinemia is a condition in which there are very low levels of immunoglobulins in the body. Immunoglobulins are a type of antibodies that protect the body from infections. As a result, individuals with Agammaglobulinemia are highly susceptible to infection from bacteria and viruses, and are often unable to fight these infections on their own
• Agammaglobulinemia can be categorized into the following types:
  • Early-onset Bruton’s Agammaglobulinemia (X-Linked Agammaglobulinemia or XLA)
  • Early-onset Agammaglobulinemia not due to Bruton’s       
  • Adult-onset common variable immunodeficiency
• Bruton’s Agammaglobulinemia is the most common cause of Agammaglobulinemia, especially in children. When clinicians refer to Agammaglobulinemia, they usually mean Bruton’s Agammaglobulinemia. It is a rare X-linked genetic disorder, which usually presents after 6 months of age
• Since the mutation is located on the X chromosome, males inherit the disorder, because they only have one X-chromosome, which is defective. Females have two X-chromosomes and even if one is defective, the other good chromosome may dominate and not let the condition get manifested
• Individuals with the disorder have difficulties producing the antibodies (gamma globulins) in blood plasma. They often experience frequent infections such as a bronchitis, diarrhea, eye infections, ear infections, and sinus infections
• The treatment options for Agammaglobulinemia may include antibody replacement through gamma globulin therapy and treating infections with appropriate antibiotics
• The prognosis for Agammaglobulinemia is generally good with appropriate therapy. Without treatment, deadly infections may develop and the condition may progress to chronic infections and decrease the lifespan of the individual

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