Hepatic Graft Rejection

Hepatic Graft Rejection

Article
Digestive Health
Diseases & Conditions
+1
Contributed byKrish Tangella MD, MBAApr 03, 2018

The topic Hepatic Graft Rejection you are seeking is a synonym, or alternative name, or is closely related to the medical condition Transplant Rejection of Liver.

Quick Summary:

  • Liver transplantation is a procedure to surgically remove a damaged or diseased liver and replace it with a healthy liver, from a compatible donor. A donor liver can either come from a deceased organ donor or from a live organ donor
  • Transplant Rejection of Liver occurs when the immune system of the recipient recognizes the new liver as being foreign and thus, harmful to the body. In other words, the body recognizes the donor liver tissue as foreign and reacts against it
  • Every individual has an immune system that ensures that no foreign particle or material enters the body. Sometimes, when there is an entry of a foreign substance, the body automatically starts to react or fight against the substance, in order to eliminate it from the body
  • The immune cells attack the foreign object, in this case, the donor liver, in an attempt to destroy it, if they do not recognize the antigens of the newly transplanted liver
  • Antigens are foreign entities that get introduced in the body, against which antibodies are produced to render them harmless. Hence the need for matching the ‘donor’ to the ‘recipient’ as immunologically close as possible, by using tissue-typing techniques
  • Some risk factors for Transplant Rejection of Liver include a prior history of organ rejection, certain medications, infection in the liver, or abnormalities in the donated liver
  • Due to Graft Rejection of Liver, there may be fever, jaundice, formation of dark urine, abdominal pain and swelling, and a general feeling of illness. The condition is diagnosed through a physical exam, laboratory tests for liver function, and a liver biopsy
  • Generally, the condition is treated using immunosuppressive medications. The prognosis of Transplant Rejection of Liver is satisfactory, with current advances in treatment
  • However, if the signs and symptoms are severe and there is a delay in the diagnosis, the outcome may be poor

Please find comprehensive information on Transplant Rejection of Liver regarding definition, distribution, risk factors, causes, signs & symptoms, diagnosis, complications, treatment, prevention, prognosis, and additional useful information HERE.

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Krish Tangella MD, MBA

Pathology, Medical Editorial Board, DoveMed Team

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