Hamartomatous Intestinal Polyposis

Hamartomatous Intestinal Polyposis

Article
Ear, Nose, & Throat (ENT)
Dental Health
+9
Contributed byKrish Tangella MD, MBAMar 16, 2022

The topic Hamartomatous Intestinal Polyposis you are seeking is a synonym, or alternative name, or is closely related to the medical condition Peutz-Jeghers Syndrome.

Quick Summary:

  • Peutz-Jeghers Syndrome (PJS) is a rare autosomal dominant condition that increases one’s susceptibility to developing polyps and certain malignancy types. PJS is a cancer predisposition syndrome. It is associated with a mutation in the STK11 gene
  • Polyps associated with Peutz-Jeghers Syndrome typically occur in the small intestine (in 95% of the cases), typically termed hamartomatous polyps. In the remaining number of cases, PJS manifest as polyps in the large intestine (colon) and stomach. The polyps generally develop at a young age, before one reaches adolescence or early adulthood
  • Some common signs and symptoms associated with Peutz-Jeghers Syndrome include the presence of intestinal polyps, abdominal pain, vomiting, and changes in breast tissue texture. PJS is also characterized by dark macules in the mucosal regions such as the mouth, eyes, nostrils, and anus
  • Peutz-Jeghers Syndrome is generally diagnosed through symptom assessment and genetic testing. The detection of gastrointestinal cancers may include imaging studies (colonoscopy). Breast cancer can be diagnosed with mammograms and tissue biopsies
  • Some possible complications of Peutz-Jeghers Syndrome include the development of highly malignant tumors, anemia from chronic bleeding, and treatment-associated side effects
  • The treatment of Peutz-Jeghers Syndrome may involve surgery (to remove benign and malignant tumors) and other modalities such as radiation therapy and chemotherapy. The overall outcomes depends on the type and severity of the associated cancer, which can vary from one individual to another

Please find comprehensive information on Peutz-Jeghers Syndrome regarding definition, distribution, risk factors, causes, signs & symptoms, diagnosis, complications, treatment, prevention, prognosis, and additional useful information HERE.

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Krish Tangella MD, MBA

Pathology, Medical Editorial Board, DoveMed Team

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