The topic Erythema Multiforme Major you are seeking is a synonym, or alternative name, or is closely related to the medical condition Erythema Multiforme.

Quick Summary:

• Erythema Multiforme (EM) is an acute, benign skin condition with a sudden onset that usually occurs due to medications, infections, illnesses, or for unknown reasons. It is described as an immune-mediated type IV hypersensitivity reaction (abnormal sensitivity to a substance)
• Typically, the condition is a self-limiting and non-progressive illness, but may recur in up to a third of the individuals
• It is classified clinically into many types: (controversy still exists regarding how it is classified)
  • Erythema Multiforme Minor with skin involvement
  • Erythema Multiforme Major with less than 10% skin involvement (of the whole body) and involvement of the mucous membrane
  • Steven-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN): This is the most severe form of Erythema Multiforme. Historically it has been considered as type of EM, but currently researchers believe it to be a different entity altogether
• The classic skin lesion is described as "target" lesions, with 3 circumferential zones of erythematous color change with central clearing like a “bulls-eye”. There may or may not be mucosal surface, such as oral cavity, involvement
• The management of Erythema Multiforme mainly involves treating the symptoms, stopping the offending agents, such as medications, and treating the underlying condition that caused EM
• Prognosis of Erythema Multiforme Minor is usually good with skin lesions disappearing spontaneously in 2-6 weeks. Whereas, the prognosis of other severe forms of EM depend on how much skin area is involved and on the prognosis of the underlying conditions. In severe cases, it may even result in death

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