The topic Double-Hit B-Cell Lymphoma you are seeking is a synonym, or alternative name, or is closely related to the medical condition Double Hit Lymphoma.

Quick Summary:

• Double Hit Lymphoma (DHL) is a highly uncommon and aggressive B-cell non-Hodgkin lymphoma. It generally affects elderly adults. The lymphoma is called ‘double hit’ because unlike a vast majority of lymphomas that have a single genetic mutation, the Double Hit Lymphoma has 2 mutations
• In general, there are many subtypes of lymphomas such as diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), mantle cell lymphoma (MCL), etc. Any subtype of non-Hodgkin lymphoma can result from a Double Hit Lymphoma; in other words, one can see a DHL in any lymphoma subtype. However, most commonly, a DHL occurs in the diffuse large B-cell type of lymphoma (an aggressive form of lymphoma)
• There are no well-established risk factors for Double Hit Lymphoma. DHL occurs due to genetic mutations that may result in abnormal development of lymphocytes, leading to the formation of cancerous cells
• Double Hit Lymphoma is a systemic condition that may involve any part of the body such as the peripheral blood, lymph nodes, bone marrow, and various organ systems. The signs and symptoms of the condition will be dependent upon the body site or organ affected
• An early and aggressive treatment of Double Hit Lymphoma is necessary, since it is a rapidly progressing disease. This may involve intensive chemotherapy and radiation therapy, depending upon the healthcare provider’s assessment of the condition
• The prognosis of Double Hit Lymphoma depends on many factors including the subtype and stage of lymphoma, progression of the condition, response to treatment, and overall health of the individual. However, typically the prognosis of DHL is poor

General information on lymphoma and lymphocytes:

• Lymphoma is a type of cancer stemming from uncontrollably dividing lymphocytes (type of white blood cells). There are two types of lymphomas:
  • Hodgkin lymphoma
  • Non-Hodgkin lymphoma
• Lymphocytes are the main white blood cells found in the lymph, which is the fluid of the lymphatic system; just as blood is the fluid of the circulatory system
• Lymphocytes are made in bone marrow, and can develop into either B-cells or T-cells. Gastrointestinal Follicular Lymphoma arises from cancerous B-cells
• Lymph results from filtration of blood as it travels to and from tissues. Lymph is colorless because it lacks red blood cells; instead, it contains lymphocytes. It is central to the immune system
• There are 3 different kinds of lymphocytes:
  • T-lymphocytes or T cells: They help combat infections and abnormalities within the cells (cell-mediated immunity). They fight viruses and cancerous cells
  • B-lymphocytes or B cells: They produce antibodies that are bodily defense proteins, which target foreign invaders outside the cells (humoral immunity). They fight bacterial cells, cell fragments, and other immunogenic elements
  • Natural killer cells or NK cells: They perform diverse functions related to both cell-mediated and humoral immunity. They also scout for cancer cells, a process called immune surveillance

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