Donath-Landsteiner Hemolytic Anemia

Donath-Landsteiner Hemolytic Anemia

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Kids' Zone
Diseases & Conditions
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Contributed byKrish Tangella MD, MBAJan 28, 2022

The topic Donath-Landsteiner Hemolytic Anemia you are seeking is a synonym, or alternative name, or is closely related to the medical condition Paroxysmal Cold Hemoglobinuria.

Quick Summary:

  • Paroxysmal Cold Hemoglobinuria (PCH) is a rare autoimmune hemolytic anemia (AIHA) disease in which the body’s immune system makes antibodies against one’s own red blood cells. It is also known as Donath-Landsteiner Syndrome
  • The condition is more common among children and those that live in cold environments. Individuals, especially children, are more likely to contract Paroxysmal Cold Hemoglobinuria if they have a bacterial or viral infection and travel from a cold to warm climate
  • Paroxysmal Cold Hemoglobinuria can show symptoms 1-2 weeks following an initial bacterial or viral infection; the common signs and symptoms noted include brownish urine, fatigue, and jaundice. PCH is diagnosed by a healthcare professional following a careful medical examination and via specialized assessments and blood tests
  • Individuals with Paroxysmal Cold Hemoglobinuria usually recover spontaneously once the infection associated with PCH is taken care of. During this time, one must avoid cold temperatures. Once the damaged red blood cells are replaced naturally by the body, the signs and symptoms subside
  • For most individuals with Paroxysmal Cold Hemoglobinuria, the prognosis is good, as long as cold environments are avoided and proper treatment is received. The condition is known to resolve spontaneously in many cases

Please find comprehensive information on Paroxysmal Cold Hemoglobinuria regarding definition, distribution, risk factors, causes, signs & symptoms, diagnosis, complications, treatment, prevention, prognosis, and additional useful information HERE.

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Krish Tangella MD, MBA

Pathology, Medical Editorial Board, DoveMed Team

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