The topic Diffuse Large B-Cell Lymphoma of Skin you are seeking is a synonym, or alternative name, or is closely related to the medical condition Primary Cutaneous Diffuse Large B-Cell Lymphoma.

Quick Summary:

• Primary Cutaneous Diffuse Large B-Cell Lymphoma (PCDLBCL) is a cutaneous B-cell non-Hodgkin’s lymphoma. It is a type of diffuse large B-cell lymphoma that affects middle-aged and older adults
• This is a type of primary cutaneous non-Hodgkin lymphoma, which means that it is a lymphoma that originates first in the skin. It can later involve other parts of the body including the lymph nodes and bone marrow. This is called systemic Primary Cutaneous Diffuse Large B-Cell Lymphoma
• There are different subtypes of Primary Cutaneous Diffuse Large B-Cell Lymphoma. They include:
  • Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type
  • T-Cell/Histiocytic-Rich Large B-Cell Lymphoma of Skin
  • Plasmablastic Lymphoma of Skin
  • Intravascular Large B-Cell Lymphoma of Skin
  • Lymphomatoid Granulomatosis of Skin
  • Cutaneous Diffuse Large B-Cell Lymphoma, Other
• The signs and symptoms of Primary Cutaneous Diffuse Large B-Cell Lymphoma may include the development of painless skin nodules on the body, which may ulcerate. If the whole body is affected then systemic signs and symptoms may also be observed
• Since, the skin is affected; the treatment is focused on addressing skin-related signs and symptoms using treatment measures that include topical medications, phototherapy, and localized radiation. Systemic therapy for Primary Cutaneous Diffuse Large B-Cell Lymphoma may be employed when other parts of the body are involved
• The prognosis depends on many factors including the progression of the condition, response to treatment, and overall health of the individual. In general, the prognosis is guarded and is based upon the stage of the tumor

General information on lymphoma and lymphocytes:

• Lymphoma is a type of cancer stemming from uncontrollably dividing lymphocytes (type of white blood cells). There are two types of lymphomas:
  • Hodgkin lymphoma
  • Non-Hodgkin lymphoma
• Lymphocytes are the main white blood cells found in the lymph, which is the fluid of the lymphatic system; just as blood is the fluid of the circulatory system
• Lymphocytes are made in bone marrow, and can develop into either B-cells or T-cells. Primary Cutaneous Diffuse Large B-Cell Lymphoma arises from cancerous B-cells
• Lymph results from filtration of blood as it travels to and from tissues. Lymph is colorless because it lacks red blood cells; instead, it contains lymphocytes. It is central to the immune system
• There are 3 different kinds of lymphocytes:
  • T-lymphocytes or T cells: They help combat infections and abnormalities within the cells (cell-mediated immunity). They fight viruses and cancerous cells
  • B-lymphocytes or B cells: They produce antibodies that are bodily defense proteins, which target foreign invaders outside the cells (humoral immunity). They fight bacterial cells, cell fragments, and other immunogenic elements
  • Natural killer cells or NK cells: They perform diverse functions related to both cell-mediated and humoral immunity. They also scout for cancer cells, a process called immunosurveillance

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