The topic Complement Dysregulation-Associated aHUS you are seeking is a synonym, or alternative name, or is closely related to the medical condition Atypical Hemolytic-Uremic Syndrome.

Quick Summary:

• Atypical Hemolytic-Uremic Syndrome (aHUS) is a very rare, life-threatening disorder that is caused by the abnormal activation of complement system. The complement system is part of the immune system that protects the body from infectious organisms
• aHUS is a chronic condition that may affect any individual at any age. The main feature of this condition is the formation of blood clots in the small blood vessels, which is known as systemic thrombotic microangiopathy (or TMA). Any organ may be affected, but the commonly affected organs include the brain, heart, kidney, and gastrointestinal tract
• Atypical Hemolytic-Uremic Syndrome has 3 major features:
  • Hemolytic anemia
  • Decreased platelets (thrombocytopenia)
  • Kidney failure
• Abnormal activation of the complement system in aHUS could be triggered by chemotherapy, infections (bacterial, viral), major transplant surgery, and even pregnancy
• A combination of environmental and genetic factors is reported to cause Atypical Hemolytic-Uremic Syndrome. Mutations in the genes involved in the normal functioning of the complement system are reported to be the cause of aHUS. However, Idiopathic Atypical Hemolytic-Uremic Syndrome could occur even without genetic mutations in an individual, due to unknown cause(s)
• The symptoms of Atypical Hemolytic-Uremic Syndrome could include abdominal pain, low urine output, jaundice, weakness, and abnormal bleeding. The diagnosis of aHUS may involve several tests of the blood, urine, genetic tests, tests for Escherichia coli to eliminate Hemolytic-Uremic Syndrome or HUS (which is caused by the bacterium), etc.
• If left untreated, many complications could arise as a result of aHUS. These might include acute kidney failure, end-stage kidney disease, liver malfunction (leading to jaundice), clot formation leading to damage to the heart (heart attack) and brain (stroke)
• Lifelong treatment and therapy may be required to manage Atypical Hemolytic-Uremic Syndrome, which may involve dialysis, plasma exchange and even a kidney transplant, if necessary
• The prognosis of Atypical Hemolytic-Uremic Syndrome depends upon several factors, the extent of organ damage (particularly kidney damage), and the health status of the individual. Nevertheless, despite intensive and timely treatment, the long range prognosis of aHUS is unpredictable

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