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Acro-Osteolysis Syndrome

Last updated May 11, 2019

Approved by: Maulik P. Purohit MD, MPH

Gorham-Stout Disease (GSD) is a very rare, progressive disorder of the bone. It is characterized by bone loss (or osteolysis), and a swelling or abnormal growth of blood vessels (angiomatous proliferation) and lymph vessels (lymphangiomatous proliferation), inside the bones.


The topic Acro-Osteolysis Syndrome you are seeking is a synonym, or alternative name, or is closely related to the medical condition Gorham-Stout Disease.

Quick Summary:

  • Gorham-Stout Disease (GSD) is a very rare, progressive disorder of the bone. It is characterized by bone loss (or osteolysis), and a swelling or abnormal growth of blood vessels (angiomatous proliferation) and lymph vessels (lymphangiomatous proliferation), inside the bones
  • The exact cause of the disorder is not known. However, there are theories for the development of GSD, which include abnormalities in blood circulation, and a shift in ratio of bone-generating to bone-destroying cells that may be triggered by trauma
  • The signs and symptoms of Gorham-Stout Disease may vary among the affected individuals. The bones of the shoulder, skull, jaws, and pelvic girdle, are affected the most. There may be pain, swelling, or fracture of the affected bones. The condition may also lead to bone loss, fibrous tissue formation in areas of bone loss, dental and facial deformities, and breathing difficulties
  • The diagnosis of the condition may involve imaging studies and biopsy of affected bones. Gorham-Stout Disease is generally diagnosed through a process of exclusion; by excluding other conditions with similar presentations
  • Gorham-Stout Disease is treated with radiation therapy, medicines to stop bone destruction, and surgery. If complications such as pathological fractures and accumulation of fluid in the lungs and heart are noted, additional treatments may be necessary
  • The outcome of Gorham-Stout Disease is determined by the severity of the condition, the affected body parts, and the general health of the affected individual. In case of severe symptoms, the outlook may be guarded

Please find comprehensive information on Gorham-Stout Disease regarding definition, distribution, risk factors, causes, signs & symptoms, diagnosis, complications, treatment, prevention, prognosis, and additional useful information HERE.

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Reviewed and Approved by a member of the DoveMed Editorial Board
First uploaded: April 8, 2017
Last updated: May 11, 2019