The risk factors for Familial Mediterranean Fever are:
It is important to note that having a risk factor does not mean that one will get the condition. A risk factor increases ones chances of getting a condition compared to an individual without the risk factors. Some risk factors are more important than others.
Also, not having a risk factor does not mean that an individual will not get the condition. It is always important to discuss the effect of risk factors with your healthcare provider.
Autosomal recessive: Autosomal recessive conditions are traits or disorders that occur when two copies of an abnormal gene have been inherited on a non-sex chromosome. If both parents have an autosomal recessive condition, there is a 100% likelihood of passing on the mutated genes to their children. If, however, only one mutant copy of the gene is inherited, the individual will be a carrier of the condition, but will not be present with any symptoms. Children born to two carriers, have a 25% chance of being homozygous dominant (unaffected), a 50% chance of being heterozygous (carrier), and a 25% chance of being homozygous recessive (affected).
Once the disorder sets in during the period of early childhood, the signs and symptoms appear at regular intervals, which then subside within 12 hours to 3 days. Common clinical presentations of Familial Mediterranean Fever are:
Diagnostic tests and procedures undertaken to determine Familial Mediterranean Fever include:
Many clinical conditions may have similar signs and symptoms. Your healthcare provider may perform additional tests to rule out other clinical conditions to arrive at a definitive diagnosis.
If treatment is delayed or absent, then certain complications may develop due to Familial Mediterranean Fever, and these may include:
There is no cure for Familial Mediterranean Fever - it is treated symptomatically. This can help in:
Since, Familial Mediterranean Fever is autosomal recessive - a careful selection, combined with medical evaluation of both you and your spouse, if you belong to a Mediterranean ancestry, may help prevent the condition from developing in your children.
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