What are the other Names for this Condition? (Also known as/Symptoms)

• Inverting Papilloma of Sinonasal Tract
• Ringertz Tumor
• Transitional Papilloma of Sinonasal Tract

What is Schneiderian Papilloma? (Definition/Background Information)

• Schneiderian Papilloma is a non-cancerous tumor condition that is characterized by the presence of an abnormal growth within the sinonasal tract (the nasal cavity). Schneiderian Papillomas account for 0.5-4% of all nasal tumors
• There are three types of Schneiderian Papillomas and these include:
  • Exophytic Papilloma or Fungiform Papilloma: This is the most common type; about 50% of the tumors are of this type. It may be associated with human papilloma virus (HPV) subtypes 6 or 11
  • Inverted Papilloma: This is also a common type; about 50% of the tumors are of this type. It may be associated with HPV subtypes 6 or 11
  • Oncocytic Papilloma or Cylindrical Papilloma: It is rare and only about 2% of all Schneiderian Papillomas belong to this type. It is not associated with HPV infections
• The causative factors for Schneiderian Papilloma include viral infections and pollution. The typical symptoms are headache, inability to smell, facial swelling, etc.
• The treatment options for Schneiderian Papilloma include therapy for symptoms and surgery when warranted. Recurrence of the condition after surgery is common

Who gets Schneiderian Papilloma? (Age and Sex Distribution)

• Schneiderian Papilloma is seen to affect individuals primarily in the 40-70 year’ age group. The tumor is unlikely to be present in children
• Even though both male and female genders are affected, men are four-times more likely to be affected than women
• Schneiderian Papilloma is a rare condition most commonly found among the Caucasian population

What are the Risk Factors for Schneiderian Papilloma? (Predisposing Factors)

The risk factors for developing Schneiderian Papilloma include the following:

• Males are commonly affected (nearly 80% of the cases are observed in them)
• Individuals of Caucasian descent are affected more than those of other racial or ethnic groups

It is important to note that having a risk factor does not mean that one will get the condition. A risk factor increases ones chances of getting a condition compared to an individual without the risk factors. Some risk factors are more important than others.

Also, not having a risk factor does not mean that an individual will not get the condition. It is always important to discuss the effect of risk factors with your healthcare provider.

What are the Causes of Schneiderian Papilloma? (Etiology)

Schneiderian Papillomas are tumors that affect the sinuses. The causative factors for this condition are being researched. However, it has been suggested that:

• Extrinsic factors, such as pollution and industrial contaminants, could potentially lead to the condition
• Viruses, such as human papilloma virus (HPV), may play a role in giving rise to the condition

What are the Signs and Symptoms of Schneiderian Papilloma?

Schneiderian Papilloma is known to cause one or more of the following signs and symptoms:

• Severe headaches
• An inability to smell due to obstruction in the nasal cavity
• Complaints of double vision and droopy eyelids
• Severe pain in the hands
• Noticeable swelling in the facial region

How is Schneiderian Papilloma Diagnosed?

A physician may employ one or more of the following to arrive at an accurate diagnosis of Schneiderian Papilloma:

• A physical examination in which a unilateral polypoidal mass filling up the nasal cavity area may be felt. The mass may appear as a reddish-gray overgrowth that fills almost the entire nasal cavity region
• Tissue biopsy: A tissue biopsy is performed and sent to a laboratory for a pathological examination, who examines the biopsy under a microscope. After putting together clinical findings, special studies on tissues (if needed) and with microscope findings, the pathologist arrives at a definitive diagnosis
• An imaging study to investigate the extent and spread of the papilloma, such as via a CT scan of the head and neck region

Many clinical conditions may have similar signs and symptoms. Your healthcare provider may perform additional tests to rule out other clinical conditions to arrive at a definitive diagnosis.

What are the possible Complications of Schneiderian Papilloma?

The complications of Schneiderian Papilloma generally arise following surgery to remove the tumor. These may include:

• Abnormalities that occur along the region of the eye, such as double vision or accumulation of fluid
• High possibility for damaging the optic nerve during surgery
• Infections, from fluid accumulation or obstruction, which creates a block in the sinonasal tract
• About 3% of the individuals with Schneiderian Papilloma can have an associated invasive carcinoma

How is Schneiderian Papilloma Treated?

• Individuals who are affected with the condition may be treated for their secondary symptoms that arise with the condition (such as sinusitis)
• Surgery is reported to be the favored treatment option for Schneiderian Papilloma by many medical professionals
• Radiation therapy is sometimes recommended, if the physician opines that it could be beneficial for the patient, and if the condition is associated with malignancy

How can Schneiderian Papilloma be Prevented?

Currently, there are no known preventive methods reported for Schneiderian Papilloma.

What is the Prognosis of Schneiderian Papilloma? (Outcomes/Resolutions)

• The prognosis for Schneiderian Papilloma is good if the mass is completely removed surgically
• Schneiderian Papillomas are known to recur, and therefore, individuals who have been treated for the condition are advised to follow-up with their physician for at least 5 years, to monitor the condition and detect early recurrences

Additional and Relevant Useful Information for Schneiderian Papilloma:

The following DoveMed website link is a useful resource for additional information:

http://www.dovemed.com/diseases-conditions/rare-disorders/