What are the other Names for this Condition? (Also known as/Synonyms)

• Piezogenic Papules of Wrist 

What is Piezogenic Wrist Papules? (Definition/Background Information)

• Piezogenic Wrist Papules is a common, benign papule of the soft tissue, which can occur in the wrist 
• The term ‘piezogenic’ means occurring due to pressure; and ‘papules’ are small, well-defined (with clear borders), normally colored or discolored, raised skin bumps
• In a majority of the cases, single papules are observed on the wrist; though rarely, it may occur as multiple papules
• The risk factors for Piezogenic Wrist Papules include Ehlers-Danlos syndrome, Prader-Willi syndrome, and obesity. However, the cause of the condition is unknown
• A complete surgical excision of Piezogenic Wrist Papule is considered curative. The prognosis of the skin papule is excellent on its complete surgical removal

Who gets Piezogenic Wrist Papules? (Age and Sex Distribution)

• Piezogenic Wrist Papules can occur at any stage of life
• It is more common in females than in males, though both are affected
• The condition is observed worldwide and no geographical localization has been reported
• There is also no ethnic or racial preference for the condition

What are the Risk Factors for Piezogenic Wrist Papules? (Predisposing Factors)

The risk factors for Piezogenic Wrist Papules include:

• Ehler-Danlos syndrome
• Prader-Willi syndrome
• Performing excessive weight-bearing exercises or participating in similar sports
• Being overweight or obese (obese women are particularly at risk)
• Rigorous physical activity

It is important to note that having a risk factor does not mean that one will get the condition. A risk factor increases ones chances of getting a condition compared to an individual without the risk factors. Some risk factors are more important than others.

Also, not having a risk factor does not mean that an individual will not get the condition. It is always important to discuss the effect of risk factors with your healthcare provider. 

What are the Causes of Piezogenic Wrist Papules? (Etiology)

• The cause of Piezogenic Wrist Papules is unknown
• The condition does not usually run within families

What are the Signs and Symptoms of Piezogenic Wrist Papules?

Most Piezogenic Wrist Papules are asymptomatic and no specific signs and symptoms may be observed. However, in others, a wide-range of behavior is observed such as:

• Usually, the presence of a solitary papule under the skin is noticed. Rarely, the papule can occur as multiple papules too
• They are typically less than 1 cm in size (along the larger dimension)
• The papules usually occur in the subcutaneous tissue in the wrist, and it may occasionally affect both wrists (bilateral presentation)
• The papular mass on skin may be occasionally painful

The timing of the signs and symptoms are important to determine the type of papule. Piezogenic Wrist Papules develop steadily over weeks to months.

How is Piezogenic Wrist Papules Diagnosed?

The following are the diagnostic tools for Piezogenic Wrist Papules:

• A thorough physical examination and a complete medical history are very crucial
• Dermoscopy: Dermoscopy is a diagnostic tool where a dermatologist examines the skin, using a special magnified lens
• Tissue biopsy of the papule: A tissue biopsy is performed and sent to a laboratory for a pathological examination, who examines the biopsy under a microscope. After putting together clinical findings, special studies on tissues (if needed) and with microscope findings, the pathologist arrives at a definitive diagnosis
• Sometimes, the pathologist may perform special studies, which may include immunohistochemical stains, histochemical stains, molecular testing, and very rarely, electron microscopic studies. Examination of the biopsy under a microscope by a pathologist is considered to be gold-standard in arriving at a conclusive diagnosis
• Differential diagnosis, to eliminate other papule types are often considered, before arriving at a definitive diagnosis

Many clinical conditions may have similar signs and symptoms. Your healthcare provider may perform additional tests to rule out other clinical conditions to arrive at a definitive diagnosis. 

What are the possible Complications of Piezogenic Wrist Papules?

There are no reports of any significant complications developing from Piezogenic Wrist Papules. 

How is Piezogenic Wrist Papules Treated?

In most cases, no treatment is necessary for Piezogenic Wrist Papules, since they are self-limiting and asymptomatic. A complete regression of the papules may also take place.

When required, the following methods may be effectively considered in their treatment:

• Steroid injection at papule site
• Weight reduction (in case of obesity)
• Decreasing weight-bearing exercises
• Surgical treatment:
  • Surgical procedures may be adopted only if non-surgical measures are unsuccessful
  • A complete surgical excision of the papule is generally considered curative     

In case no surgery is required, the patient may be reassured that Piezogenic Wrist Papules are benign lesions.

How can Piezogenic Wrist Papules be Prevented?

Eliminating the modifiable risk factors helps in the prevention of Piezogenic Wrist Papules. These may include:

• Reduce weight-bearing exercises
• Decrease weight (if obese or overweight) 

What is the Prognosis of Piezogenic Wrist Papules? (Outcomes/Resolutions)

The prognosis of Piezogenic Wrist Papules is excellent with appropriate treatment. 

Additional and Relevant Useful Information for Piezogenic Wrist Papules:

The following DoveMed website link is a useful resource for additional information:

https://www.dovemed.com/diseases-conditions/rare-disorders/