A research study conducted by scientists at the University College of London and Oxford University finds that serotonin-enhancing antidepressants increased aversion to inflicting harm on oneself or others, while a dopamine-increasing drug commonly used for Parkinson’s disease decreased altruistic tendencies.
Human beings usually operate on a moral code of avoiding harm to others. However, in individuals with anti-social tendencies, the moral core is diminished/disturbed, which reportedly forms the basis for aggressive behavior. Serotonin and dopamine are both known to promote aggressive behavior, and the current study was undertaken to understand the effect of drugs that enhance their levels.
In this research study, a total of 175 healthy adults were recruited. This was a randomized study in which 170 trials were conducted. The study design was as follows:
The results showed that:
The lead author of the study, Dr. Molly Crockett said in the Press Release of the American Association for the Advancement of Science, "Our findings have implications for potential lines of treatment for antisocial behavior, as they help us to understand how serotonin and dopamine affect people's willingness to harm others for personal gain. We have shown that commonly prescribed psychiatric drugs influence moral decisions in healthy people, raising important ethical questions about the use of such drugs.”
The participants in the study were healthy, as opposed to the real world where people take the drugs used in this investigation for the treatment of conditions. Whether these drugs have similar, different, or more pronounced effects on patients compared to healthy subjects remains to be seen. In the authors’ opinion, “These distinct roles of serotonin and dopamine in modulating moral behavior have implications for potential treatments of social dysfunction that is a common feature as well as a risk factor for many psychiatric disorders.”
Written by Mangala Sarkar Ph.D.
Primary References:
Commonly prescribed drugs affect decisions to harm oneself and others. (n.d.). Retrieved July 6, 2015, from http://www.eurekalert.org/pub_releases/2015-07/ucl-cpd062915.php
Crockett, M., Siegel, J., Kurth-Nelson, Z., Ousdal, O., Story, G., Frieband, C., . . . Dolan, R. (2015). Dissociable Effects of Serotonin and Dopamine on the Valuation of Harm in Moral Decision Making. Current Biology.
DOI: http://dx.doi.org/10.1016/j.cub.2015.05.021
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