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Drug Targeting Technique Could Aid Therapies For Immune Diseases

Last updated Oct. 6, 2017

A new technique that targets drugs to specific cells could lead to improved therapies for diseases caused by an overactive immune response.

The approach could help people affected by conditions such as arthritis and inflammatory bowel diseases, where the body's own immune system mistakenly attacks healthy tissues.

Researchers focused on a group of immune cells called macrophages -- some of which help the body heal after injury, while others can promote harmful inflammation.

The team at the University of Edinburgh sought to devise a new therapy to remove harmful macrophages while leaving healing cells unaffected

They coupled a drug compound to a carrier molecule that only becomes active in acidic conditions, such as those found inside harmful macrophages.

A fluorescent tag attached to the molecules enabled the team to track the cells affected by the drug.

Lab tests on human macrophages showed the treatment preferentially affected inflammatory macrophages and did not affect healing cells.

Studies with zebrafish, which share features of their immune system with people, found the treatment helped to improve the recovery of tissues after injury.

The team hopes their approach could lead to more effective therapies, with fewer side effects, for the treatment of immune-related diseases.

Their research was published in the journal ACS Central Science.

Dr Marc Vendrell, of the Medical Research Council Centre for Inflammation Research at the University of Edinburgh, who led the study, said: "This is an important step forward in the design of more precise drugs with fewer side effects. In future studies, we want to exploit this technology to improve the treatment of diseases in which macrophages and immune cells are important."


Materials provided by University of EdinburghNote: Content may be edited for style and length.

Disclaimer: DoveMed is not responsible for the accuracy of the adapted version of news releases posted to DoveMed by contributing universities and institutions.

References:

Antonio Fernandez, Matthieu Vermeren, Duncan Humphries, Ramon Subiros-Funosas, Nicole Barth, Lara Campana, Alison MacKinnon, Yi Feng, Marc Vendrell. (2017). Chemical Modulation of in Vivo Macrophage Function with Subpopulation-Specific Fluorescent Prodrug ConjugatesACS Central Science. DOI: 10.1021/acscentsci.7b00262

Reviewed and Approved by a member of the DoveMed Editorial Board
First uploaded: Oct. 6, 2017
Last updated: Oct. 6, 2017

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