The topic Cutaneous T-Cell/Histiocytic-Rich Large B-Cell Lymphoma you are seeking is a synonym, or alternative name, or is closely related to the medical condition T-Cell/Histiocyte-Rich Large B-Cell Lymphoma of Skin.

Quick Summary:

• T-Cell/Histiocyte-Rich Large B-Cell Lymphoma (T/HRBCL) of Skin is a cutaneous B-cell non-Hodgkin’s lymphoma. It is an uncommon variant of diffuse large B-cell lymphoma affecting middle-aged adults
• This is a type of primary cutaneous non-Hodgkin lymphoma, which means that it is a lymphoma that originates first in the skin. It can later involve other parts of the body including the lymph nodes and bone marrow
• Nevertheless, the primary cutaneous form is very rare; it is more common for systemic lymphoma to involve skin. Also, because T-cells are mixed up with the tumor, it can cause diagnostic challenges for a pathologist
• T-Cell/Histiocyte-Rich Large B-Cell Lymphoma of Skin may be manifested as skin lesions that can grow in size and ulcerate over a period of time. A biopsy of the involved skin (or swollen lymph nodes) can help establish a diagnosis
• The treatment of T-Cell/Histiocyte-Rich Large B-Cell Lymphoma of Skin may involve a combination of chemotherapy and radiation therapy. Skin-directed therapy may be necessary when the skin symptoms are severe
• The prognosis depends on many factors including the type of lymphoma, progression of the condition, response to treatment, and overall health of the individual. In general, the prognosis of T/HRBCL of Skin is guarded and is based upon the stage of the tumor

There are different subtypes of Primary Cutaneous Diffuse Large B-Cell Lymphoma. They include:

• Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type
• T-Cell/Histiocyte-Rich Large B-Cell Lymphoma of Skin
• Plasmablastic Lymphoma of Skin
• Intravascular Large B-Cell Lymphoma of Skin
• Lymphomatoid Granulomatosis of Skin
• Cutaneous Diffuse Large B-Cell Lymphoma, Other

General information on lymphoma and lymphocytes:

• Lymphoma is a type of cancer stemming from uncontrollably dividing lymphocytes (type of white blood cells). There are two types of lymphomas:
  • Hodgkin lymphoma
  • Non-Hodgkin lymphoma
• Lymphocytes are the main white blood cells found in the lymph, which is the fluid of the lymphatic system; just as blood is the fluid of the circulatory system
• Lymphocytes are made in bone marrow, and can develop into either B-cells or T-cells. T-Cell/Histiocyte-Rich Large B-Cell Lymphoma of Skin arises from cancerous B-cells
• Lymph results from filtration of blood as it travels to and from tissues. Lymph is colorless because it lacks red blood cells; instead, it contains lymphocytes. It is central to the immune system
• There are 3 different kinds of lymphocytes:
  • T-lymphocytes or T cells: They help combat infections and abnormalities within the cells (cell-mediated immunity). They fight viruses and cancerous cells
  • B-lymphocytes or B cells: They produce antibodies that are bodily defense proteins, which target foreign invaders outside the cells (humoral immunity). They fight bacterial cells, cell fragments, and other immunogenic elements
  • Natural killer cells or NK cells: They perform diverse functions related to both cell-mediated and humoral immunity. They also scout for cancer cells, a process called immune surveillance

Please find comprehensive information on T-Cell/Histiocyte-Rich Large B-Cell Lymphoma of Skin regarding definition, distribution, risk factors, causes, signs & symptoms, diagnosis, complications, treatment, prevention, prognosis, and additional useful information HERE.