Constitutional Liver Dysfunction due to Gilbert Syndrome

Constitutional Liver Dysfunction due to Gilbert Syndrome

Article
Digestive Health
Congenital & Genetic Disorders
Contributed byKrish Tangella MD, MBAMar 25, 2018

The topic Constitutional Liver Dysfunction due to Gilbert Syndrome you are seeking is a synonym, or alternative name, or is closely related to the medical condition Gilbert Syndrome.

Quick Summary:

  • Gilbert Syndrome is an inherited condition that is caused by certain gene mutations that are passed down through family generations. Currently, there are no other risk factors associated with Gilbert Syndrome and it is inherited from one’s parents
  • Gilbert Syndrome is caused, when the defective UGT1A1 gene that cannot properly produce a necessary protein in the body, is inherited in an autosomal recessive manner. Individuals with Gilbert Syndrome do not have the protein responsible for breakdown of bilirubin (a product of red blood cells)
  • Gilbert Syndrome is typically mild and is characterized by the inability of the liver to process bilirubin. The main sign of Gilbert Syndrome is yellowing of the skin or eyes (jaundice) and feeling of tiredness. Jaundice in these individuals most usually occurs during stressful situations such as during illness, exercise, dehydration, or even during fasting
  • Complications associated with Gilbert Syndrome include being unable to receive certain drugs, including chemotherapy drugs or drugs that treat HIV. Other than avoiding these medications, there are generally no known complications associated with Gilbert Syndrome
  • Not all individuals with Gilbert Syndrome require treatment, especially if the signs and symptoms are mild. The body levels of bilirubin often change and if they increase enough, the condition may manifest as jaundice. However, this is self-resolving, and the levels of bilirubin automatically decrease on their own with no adverse effects after some time
  • There is no known prevention of Gilbert Syndrome, since this disorder is passed down families. The episodes of high bilirubin levels in blood can be prevented, however, by preventing strenuous exercise, periods of fasting, or other stressful conditions
  • Gilbert Syndrome has a good prognosis and individuals who have this disorder generally live a normal and healthy life

Please find comprehensive information on Gilbert Syndrome regarding definition, distribution, risk factors, causes, signs & symptoms, diagnosis, complications, treatment, prevention, prognosis, and additional useful information HERE.

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Krish Tangella MD, MBA

Pathology, Medical Editorial Board, DoveMed Team

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