The topic Buerger Disease you are seeking is a synonym, or alternative name, or is closely related to the medical condition Thromboangiitis Obliterans (TAO).

Quick Summary:

• Thromboangiitis Obliterans (TAO) is non-atheromatous (not related to cholesterol deposition) inflammation and occlusion of the small and medium sized arteries and veins of the lower and upper extremities
• It is thought to be caused by an auto-immune reaction against a type of connective tissue (collagen type I and III), which forms the walls of the blood vessels
• There is a very strong correlation between tobacco use and this disorder. Almost all the affected patients have a strong history of tobacco smoking or chewing. Young and middle-aged male adults are affected the most by TAO
• The most important symptom of Thromboangiitis Obliterans is severe pain in the legs on walking that is relieved with rest. In case of complications, there may be ulceration of the part of the foot, infection, and gangrene formation that may require amputation of the limb
• Absolute stoppage of tobacco use is the most important treatment consideration. It is also the only preventive measure of Thromboangiitis Obliterans
• The rate of limb amputation in smokers with TAO is very high. However, if smoking is quit, then the condition has an improved prognosis

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