What is Meclofenamate Overdose?
- Meclofenamate is a non-steroidal anti-inflammatory drug (NSAID) that is used for treating some forms of arthritis (such as osteoarthritis and rheumatoid arthritis). It helps relieve symptoms of joint pain and inflammation, including muscle stiffness
- The medication is also used to control menstrual bleeding in women, when abnormally heavy bleeding takes place
- Meclofenamate Overdose is the accidental or intentional intake of the drug in dosage higher than prescribed values
- The condition is diagnosed based upon the clinical history, combination of signs and symptoms, and additional tests (that may include, in some cases, radiological studies and laboratory tests)
What are the Causes of Meclofenamate Overdose?
- Meclofenamate Overdose is caused by the intake of meclofenamate containing drug in dosage that is higher than prescribed
- This intake could be accidental, or in some cases intentional, to bring self-harm
- It is sold as Meclofen, Meclomen, and Movens among others
Note: The drug can interact with other prescribed or non-prescribed medications in the body. Such interactions may enhance the therapeutic effects of the drug or other medications being taken, resulting in undesired side effects (such as an overdose).
What are the Signs and Symptoms of Meclofenamate Overdose?
The signs and symptoms of Meclofenamate Overdose can vary from one individual to another. It may be mild in some and severe in others. Several systems of the body, such as the digestive system, nervous system, respiratory system, vascular system, skin and ENT may be affected.
The signs and symptoms of Meclofenamate Overdose may include
- Breathing difficulties; wheezing
- Nausea and vomiting (blood in vomit, in some cases)
- Abdominal or stomach pain
- Internal bleeding affecting the stomach and gastrointestinal (GI) tract
- Increased or decreased blood pressure (hypertension or hypotension respectively)
- Feeling dizzy or drowsy; lethargy or weakness
- Confusion and increased nervousness/unsteadiness
- Disorientation, mumbling (incoherence)
- Rashes or blister formation on the skin
- Numbness and tingling sensation
- Ringing in the ears
- Vision abnormalities including blurred vision
- Symptoms of congestive heart failure including chest pain, swollen legs, and breathing difficulties
How is First Aid administered for Meclofenamate Overdose?
First Aid tips for Meclofenamate Overdose:
- If the individual with Meclofenamate Overdose is in a coma, or is experiencing life-threatening symptoms, call 911 (or your local emergency help number) immediately
- Call the Poison Control Center at 1-800-222-1222 (or your local poison control center) for further instructions
- Provide them with information such as dosage, type of drug taken, strength and time of ingestion of medication, age, weight and general health status of affected individual
- Confirm that the airways are protected; also, ensure breathing and the presence of pulse
- Induce vomiting, unless NOT instructed by a healthcare professional, or if the individual is having convulsions
- Take individual to emergency room (ER) for further treatment
- Always try to take the medication strip/bottle/container to the ER
The emergency medical health professional might perform the following steps towards treating the condition:
- Gastric lavage for elimination of drug from the stomach (irrigation using special solutions)
- Medically manage symptoms, such as seizures, internal bleeding, etc.
- Provide breathing support, if necessary
- Administer activated charcoal to avoid absorbance of drug in the body
- Administer laxatives for elimination of drug from the body
- Administer fluids by an intravenous drip line
- Blood loss due to severe gastrointestinal bleeding may necessitate blood transfusion
Who should administer First Aid for Meclofenamate Overdose?
First aid for Meclofenamate Overdose is administered by healthcare professionals.
- The individual who overdosed, or someone near, should call 911 for emergency assistance (or the local emergency number)
- They should also call the poison control center at 1-800-222-1222 (or the local poison control center) and follow instructions
What is the Prognosis of Meclofenamate Overdose?
- The prognosis of Meclofenamate Overdose is dependent on the amount of drug consumed, time between overdose and treatment, severity of the presenting symptoms, as well as general health status of the patient
- If the individual can recover from the symptoms, with appropriate medication and early support, the outcome is generally good. In many cases, the common side effects of the overdose noted are stomach pain and vomiting
- In case of complications including heart failure, severe internal bleeding, and coma, it may considerably worsen the outcome. Deaths are known to occur from severe overdosing in both children and adults
In general, overdoses are common situations in the emergency departments. A majority of the cases are often not fatal, when appropriate treatment is given.
How can Meclofenamate Overdose be Prevented?
Meclofenamate Overdose can be prevented by:
- Always taking the right dose of medication at recommended times
- Avoiding drugs that might interact with meclofenamate
- Talking to your healthcare provider, if recommended dose of meclofenamate does not provide adequate relief
- Refrain from self-medication
- Exercising caution while taking multiple drugs with meclofenamate
- Keeping medications out of reach of children in child-proof containers
- For older individuals and those who tend to be forgetful, medications should be stored in single dose containers with time labels, to avoid multiple dosage
- Monitor intake of this drug especially in patients, who have depression or harbor suicidal thoughts and behavior
It is important to give your healthcare provider a complete list of prescription and non-prescription medications that are being currently taken. This will help them in assessing the possible drug interactions within various medications and help avoid/prevent accidental or unintentional toxic drug effects.
What are certain Crucial Steps to be followed?
- Call 911 (or your local emergency number) for emergency assistance, if symptoms are life-threatening
- Call Poison Control Center at 1-800-222-1222 (or the local poison control center) and follow the recommend steps
- It would be helpful if the following information is readily available:
- Type, dosage and time of administration of medication
- Age and weight of the individual
- And, the overall health status of the individual