What are the other Names for this Condition? (Also known as/Synonyms)

• NVE (Native Valve Endocarditis)

What is Native Valve Endocarditis? (Definition/Background Information)

• Infective endocarditis is an infection of the heart valves or the heart’s inner lining, known as the endocardium. Infective endocarditis is usually caused by a bacteria or a fungus
• Native Valve Endocarditis (NVE) occurs in individuals when their ‘natural’ heart valves are infected. The term ‘natural’ is used to differentiate this condition from prosthetic valve endocarditis (PVE) that occurs when the artificial ‘prosthetic’ heart valves are infected
• Native Valve Endocarditis is usually caused by the bacteria Streptococcus or Staphylococcus; in a few cases, it may be caused by a fungus. The infection from other parts of the body may enter the bloodstream (usually resulting in bacteremia) and attack the heart valves
• Native Valve Endocarditis can occur at any age, but it generally affects individuals older than 50 years of age. The risk factors for the condition include heart conditions such as rheumatoid vascular disease, congestive heart disease, and age-related degenerative heart disease
• The signs and symptoms of Native Valve Endocarditis may include low-grade fever, fatigue, and joint pain. NVE can lead to complications including congestive heart failure, cardiac arrhythmias, and neurological complications
• The treatment of Native Valve Endocarditis is based on the organism type causing the infection. Bacterial infection is treated through intravenous antibiotics and fungal infection using antifungal medication. Surgery may be required in some cases
• Untreated Native Valve Endocarditis can lead to an extremely poor prognosis and can almost always be fatal. With appropriate early diagnosis and treatment, the outcomes are better. However, the prognosis also depends upon a set of factors including the type of organism causing infection, the health status of the individual, and the presence of any heart illness, among other factors

Who gets Native Valve Endocarditis? (Age & Sex Distribution)

• Native Valve Endocarditis is mostly seen in middle-aged and elderly adults over 50 years old, though individuals of any age are at risk
• Both males and females are affected
• It may affect individuals of all racial and ethnic background and no preference is noted

Note: Individuals with normal immune function, normal heart condition, and a healthy lifestyle are not prone to Native Valve Endocarditis.

What are the Risk Factors for Native Valve Endocarditis? (Predisposing Factors)

The risk factors for Native Valve Endocarditis may include the following factors:

• Rheumatoid vascular disease
• Congestive heart disease
• Mitral valve prolapse
• Age-related degenerative heart disease
• Heart disease due to underlying connective tissue disorders
• Heart disease due to syphilis
• Any cause of bacteremia that may include medical procedures such as:
  • Oral surgery, tooth extraction
  • Abdominal surgery
  • Genitourinary surgery; prostate resection
  • Diagnostic procedures such as upper GI endoscopy, colonoscopy, and barium enema
  • Transesophageal echocardiography
  • Placement of intravascular catheters
  • Poor oral hygiene and aggressive brushing of teeth can also result in bacteremia
• Previous history of endocarditis
• Intravenous (IV) drug abuse: Needles that are used to inject illegal drugs are sometimes contaminated with bacteria, which can cause Native Valve Endocarditis
• HIV and AIDS patients, because of suppressed immune system
• Poorly-controlled diabetes
• Longstanding corticosteroid therapy

It is important to note that having a risk factor does not mean that one will get the condition. A risk factor increases ones chances of getting a condition compared to an individual without the risk factors. Some risk factors are more important than others.

Also, not having a risk factor does not mean that an individual will not get the condition. It is always important to discuss the effect of risk factors with your healthcare provider.

What are the Causes of Native Valve Endocarditis? (Etiology)

• Native Valve Endocarditis is caused by pathogenic organisms that include bacteria and fungus (in rare cases)
• NVE is mostly caused by the bacteria Streptococcus (70% of the cases) and Staphylococcus (25% of the cases)

What are the Signs and Symptoms of Native Valve Endocarditis?

The signs and symptoms of Native Valve Endocarditis may not always be severe; in many cases, it may be mild. In some, it may slowly develop over time, and hence, this may result in a delayed diagnosis. However, in some individuals, there may be a sudden onset of severe signs and symptoms.

The signs and symptoms associated with Native Valve Endocarditis may include:

• Low-grade fever, which comes and goes in a majority of individuals, and chills
• Night sweats
• Fatigue and malaise, which is a feeling of discomfort or uneasiness
• Anorexia, or the lack of appetite; weight loss
• Headache
• Arthralgia or joint pain; stiff neck and backache
• Chest pain (pleuritic pain), cough
• Confusion
• A new or changing heart murmur: It is an abnormal heart sound that can be listened with a stethoscope
• Electrical abnormalities in the heart (cardiac arrhythmias)
• Stroke: It is a condition in which blood supply to an area of the brain is disrupted that results in a weakness of certain part of the body such as an arm, leg, or face
• Formation of septic emboli within the bloodstream (septic emboli are blood clots admixed with bacteria)
• Abdominal signs and symptoms such as nausea/vomiting and abdominal pain
• Janeway lesions, which are small, painless, red or hemorrhagic lesions on the palms and sloes
• Osler’s  nodes, which are painful, red, raised lesions mostly on distal fingers
• Intracranial hemorrhage: Hemorrhage within the brain
• Conjunctival hemorrhage: Conjunctiva is a membrane that lines the inside of the eyelid and the sclera (the white part of the eye)
• Splinter hemorrhages: These are tiny blood clots under the finger nails
• Kidney and spleen infarcts: Interruption of blood supply to the kidney and spleen resulting in permanent damage of some of their portions
• Enlarged spleen
• Glomerulonephritis: Damage to the kidneys resulting in the loss of blood and proteins in the urine
• Roth’s spots: These are retinal hemorrhages and are seen with a fundoscope (an ophthalmoscope to view the inside of the eye)

How is Native Valve Endocarditis Diagnosed?

In order to diagnose Native Valve Endocarditis, the physician will initially perform a physical exam with evaluation of medical history. During a physical examination, the physician will look for the presence of the following:

• Low-grade fever
• A new or changing heart murmur
• Janeway lesions
• Osler’s nodes
• Roth’s spots
• Splinter hemorrhages
• Conjunctival hemorrhages
• Weakness/paralysis of a part of body (leg arm or face), which may be due to a brain stroke

Certain specific tests that may help in the diagnosis of Native Valve Endocarditis such as:

• Blood cultures: Blood is drawn from a vein and sent to the laboratory, where it is placed on a special dish to see the growth of the bacteria/fungus responsible for causing Infective Endocarditis
• Chest X-ray
• Echocardiography: It is an ultrasound of the heart that is performed to assess cardiac function, size of the heart chambers, and the status of heart valves
• Electrocardiogram or EKG for detecting conduction abnormalities of the heart

Endocarditis is usually diagnosed using Duke’s diagnostic criteria for endocarditis, which consists of a combination of major criteria and minor criteria. A definitive diagnosis should satisfy any of the following conditions:

• The presence of any 2 major criteria
• The presence of 1 major criterion and 3 minor criteria
• The presence of 5 minor criteria

Major criteria include the following:

• 2 blood cultures positive for infectious organisms
• Blood cultures that are positive for microorganisms, which are taken 12 hours apart
• 3 blood cultures positive on separate occasions that are taken at least 1 hour apart
• Abnormalities in echocardiogram showing either a mass or abnormal blood flow
• Abscess of the heart
• New abnormalities developing in a prosthetic valve (partial dehiscence of the valve)
• Recent onset of regurgitation of the valve causing abnormal blood flow (valvular regurgitation)

Minor criteria include the following:

• Previously diagnosed heart condition
• A positive history of intravenous drug use
• Fever above 38 deg. C
• Presence of vascular infarcts, hemorrhage, aneurysm, and emboli occurring in any part of the body
• Abnormal immune findings such as glomerulonephritis, positive rheumatoid factor, Osler nodes
• Positive blood cultures that do not meet the criteria described in the ‘major criteria’
• Abnormal echocardiogram findings not described in the ‘major criteria’

Many clinical conditions may have similar signs and symptoms. Your healthcare provider may perform additional tests to rule out other clinical conditions to arrive at a definitive diagnosis.

What are the possible Complications of Native Valve Endocarditis?

Native Valve Endocarditis, if not promptly treated can cause major complications. The complications may affect any part of the body and may include:

• Mitral and aortic valve incompetence: The bacteria/fungi clump together with other cell fragments and form aggregates of bacterial or fungal growth (vegetations) on the heart valves. If not treated promptly, it might result in permanent damage to the valves
• Congestive heart failure: Due to damaged heart valves, it is difficult for the heart to pump enough blood to meet the requirements of the body. This can eventually result in heart failure and death
• Formation of myocardial abscesses: An abscess may develop within the heart muscle and cause abnormal heartbeat rhythms (electrical conduction defects)
• Infections in other parts of the body (metastatic infections): Infected material and vegetations formed on the heart valves dislodge and travel through blood to infect other organs of the body resulting in lung, kidney, spleen, and brain abscesses
• Individuals may have neurological complications, which usually results from bleeding in the brain (intracerebral hemorrhage), embolic stroke, multiple sites of brain infection caused by microabscesses
• Heart failure; permanent heart damage

How is Native Valve Endocarditis Treated?

Native Valve Endocarditis is a serious infection and requires an early and effective treatment in a hospital setting. However, it can be completely cured if proper treatment is administered.

• Treatment of bacterial infections:
  • Intravenous antibiotics, wherein antibiotics are given through the vein. Initially an empiric antibiotic is started usually vancomycin or ceftriaxone, which is then later modified depending upon the laboratory results
  • Sometimes surgery is needed to treat persistent infections not responding to antibiotic therapy
• Treatment of fungal infections:
  • Administration of antifungal medication
  • Surgery is also sometimes needed to treat endocarditis caused by fungal organisms
• Surgical replacement of the valve with a prosthetic device, if necessary
• Surgery may be performed to remove the infected area in the heart, or to correct the heart valve abnormalities

How can Native Valve Endocarditis be Prevented?

Generally, individuals with normal immune function, normal heart condition, and a healthy lifestyle are not prone to endocarditis. Hence, the following precautionary measures can be adopted to reduce the risk of acquiring Native Valve Endocarditis:

• Practice good oral hygiene every day, which may include:
  • Regular brushing and flossing of the teeth and gums; avoid aggressive brushing of teeth
  • Have regular dental checkups
  • Ensuring that dentures fit properly
• Avoid any procedure that can potentially lead to skin infections including body piercings and tattoos
• Ensuring that strict safety and standardized practices are observed during the performance of any diagnostic tests or surgical procedures within a hospital environment
• Treat any heart-related illness or disease promptly
• Avoiding the use of intravenous drugs
• Controlling diabetes through suitable lifestyle changes
• Immediately addressing any medical issues causing poor immune system, including appropriate treatment of HIV infection and AIDS
• Frequent follow up physician visits for individuals who have been diagnosed with endocarditis in the past

Previously, every individual who was considered at risk of developing endocarditis was advised to take antibiotics as a preventive measure before any dental, gastrointestinal and urinary tract procedure was undertaken.

However, the American Heart Association recommends antibiotic prophylaxis before certain dental procedures, only for individuals who are considered to have a high risk for endocarditis. Individuals who belong to such a high risk group include those with:

• An artificial (prosthetic) heart valve
• Previous bacterial endocarditis
• Unrepaired cyanotic congenital heart diseases (birth defects with oxygen levels lower than normal) such as Tetralogy of Fallot and transposition of great vessels
• Incompletely treated congenital heart diseases
• The first 6 months following the complete treatment of congenital heart disease
• Heart valve disease that develops after a heart transplantation procedure

The American Heart Association, no longer recommends antibiotic prophylaxis prior to gastrointestinal and genitourinary procedures including gastroscopy, colonoscopy, and cystoscopy.

What is the Prognosis of Native Valve Endocarditis? (Outcomes/Resolutions)

Native Valve Endocarditis, if left untreated is almost always fatal. The prognosis depends on a set of factors that include:

• The overall health condition of the individual
• The type of organism causing infection: NVE, when caused by Staphylococcus, is more aggressive than when caused by Streptococcus
• The presence of any heart disease or heart abnormality
• Surgical procedures involving the heart
• The severity of the signs and symptoms and development of complications (if any)
• History of IV drug abuse
• Presence of other underlying conditions
• Age of the individual

With early and effective treatment, individuals with Native Valve Endocarditis have a good prognosis.

The prognosis is known to be worse for the following group of individuals:

• Older individuals
• Infection with resistant organism
• Long delay in treatment
• Aortic and multiple valve involvement
• Large vegetations or aggregates of bacterial or fungal growth
• Infection with fungal organism
• Major embolic event resulting in large damage to the kidney, spleen, or lungs

Additional and Relevant Useful Information for Native Valve Endocarditis:

Please visit our Heart & Vascular Health Center for more physician-approved health information:

http://www.dovemed.com/healthy-living/heart-center/