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Anaplastic Ganglioglioma

Last updated April 30, 2018

Approved by: Maulik P. Purohit MD MPH

Anaplastic Ganglioglioma (AGG) is a very rare type of brain tumor that is a type of ganglioglioma.


What are the other Names for this Condition? (Also known as/Synonyms)

  • AGG (Anaplastic Ganglioglioma)

What is Anaplastic Ganglioglioma? (Definition/Background Information)

  • Anaplastic Ganglioglioma (AGG) is a very rare type of brain tumor that is a type of ganglioglioma
    • In general, gangliogliomas are classified as grade I or low grade tumors, meaning that they grow slowly and are considered benign
    • Anaplastic Gangliogliomas, however, are considered grade III or high-grade tumors, which means that they are usually aggressive, malignant tumors
  • The main treatment is removal of the entire tumor during surgery. If the entire tumor is not removed, it has the potential to recur and may require additional surgery or treatments, such as radiation therapy or chemotherapy
  • Unfortunately, because gangliogliomas are quite rare, there is limited information to show that radiation therapy or chemotherapy are effective treatments for this condition

(Source: Anaplastic Ganglioglioma; Genetic and Rare Diseases Information Center (GARD) of National Center for Advancing Translational Sciences (NCATS), USA.)

Who gets Anaplastic Ganglioglioma? (Age and Sex Distribution)

  • Anaplastic Ganglioglioma is a rare form of brain tumor. Children and young adults are more frequently affected by this type of tumor
  • Both males and females may be affected
  • Worldwide, individuals of all racial and ethnic groups may be affected

What are the Risk Factors for Anaplastic Ganglioglioma? (Predisposing Factors)

  • Currently, no risk factors have been clearly identified for Anaplastic Ganglioglioma

It is important to note that having a risk factor does not mean that one will get the condition. A risk factor increases one’s chances of getting a condition compared to an individual without the risk factors. Some risk factors are more important than others.

Also, not having a risk factor does not mean that an individual will not get the condition. It is always important to discuss the effect of risk factors with your healthcare provider.

What are the Causes for Anaplastic Ganglioglioma? (Etiology)

The exact cause of formation of Anaplastic Ganglioglioma is not known at the present time.

What are the Signs and Symptoms of Anaplastic Ganglioglioma?

The signs and symptoms of Anaplastic Ganglioglioma may include the following:

  • Headaches that may worsen over time
  • Nausea
  • Seizures
  • Other neurological symptoms based on the location of the tumor

How is Anaplastic Ganglioglioma Diagnosed?

Anaplastic Ganglioglioma is diagnosed on the basis of the following information:

  • Complete physical examination
  • Thorough medical history evaluation
  • Assessment of signs and symptoms
  • Laboratory tests
  • Imaging studies
  • Biopsy studies, if necessary

Many clinical conditions may have similar signs and symptoms. Your healthcare provider may perform additional tests to rule out other clinical conditions to arrive at a definitive diagnosis.

What are the possible Complications of Anaplastic Ganglioglioma?

The complications of Anaplastic Ganglioglioma may include:

  • Risk of fall and injury due to seizures
  • Reduced social interactions due to behavioral changes
  • Metastasis of the tumor to local and distant regions

Complications may occur with or without treatment, and in some cases, due to treatment also.

How is Anaplastic Ganglioglioma Treated?

The treatment for Anaplastic Ganglioglioma may include:

  • Surgical excision of the tumor, where possible
  • Radiation therapy
  • Chemotherapy

How can Anaplastic Ganglioglioma be Prevented?

  • The exact cause or risk factors for Anaplastic Ganglioglioma are not known. Therefore, currently, no guidelines or methods are available towards preventing tumor formation
  • Active research is currently being performed to explore the possibilities for treatment and prevention of tumors such as Anaplastic Ganglioglioma
  • Regular medical screening at periodic intervals with tests and physical examinations are recommended

What is the Prognosis of Anaplastic Ganglioglioma? (Outcomes/Resolutions)

  • The prognosis of Anaplastic Ganglioglioma is dependent upon the grade of tumor, stage of the tumor, the overall health of the affected individual, and his/her response to treatment
  • Typically, the prognosis is assessed on a case-by-case basis

Additional and Relevant Useful Information for Anaplastic Ganglioglioma:

The following DoveMed website link is a useful resource for additional information:

http://www.dovemed.com/diseases-conditions/rare-disorders/

What are some Useful Resources for Additional Information?


References and Information Sources used for the Article:


Helpful Peer-Reviewed Medical Articles:


Reviewed and Approved by a member of the DoveMed Editorial Board
First uploaded: April 30, 2018
Last updated: April 30, 2018