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New Design Of Engineered Arginine Depleting Enzymes As Multi-potent Anti-Cancer Agents

Last updated Oct. 9, 2016

Approved by: Krish Tangella MD, MBA, FCAP

PolyU

Three dimensional molecular structure of thermostable Bacillus arginase (BCA).


Arginine deprivation has become a new cancer treatment paradigm and has exploited for treatment of various cancers. Arginine is an essential amino acid for the growth of cancer cells. Deprivation of arginine induces cancer cells death but it is generally well tolerated in normal cells. The successful use of Arginine Deiminase (ADI) to treat argininosuccinate synthetase (ASS)-deficient tumors has opened up new possibilities for targeted therapy. Nevertheless, many ASSpositive cancers are resistance to ADI.

By rational drug design, researchers at The Hong Kong Polytechnic University (PolyU) have developed a thermostable arginase (BCA-PEG20) to treat both ADI-sensitive and ADI-resistant cancers. BCA-PEG20 has demonstrated to have antitumor activities both in vitro and in vivo in lung cancer, liver cancer, colorectal cancer, gastric cancer, cervical cancer and other tumors. As a novel multipotent anti-cancer drug, BCA-PEG20 is able to work as a single agent and combine with other chemotherapeutic agents to enhance treatment effect.


Materials provided by The Hong Kong Polytechnic University.Note: Content may be edited for style and length.

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Primary Resource:

Tsui, S. M., Lam, W. M., Lam, T. L., Chong, H. C., So, P. K., Kwok, S. Y., ... & Leung, Y. C. (2009). Pegylated derivatives of recombinant human arginase (rhArg1) for sustained in vivo activity in cancer therapy: preparation, characterization and analysis of their pharmacodynamics in vivo and in vitro and action upon hepatocellular carcinoma cell (HCC). Cancer cell international9(1), 1.

Reviewed and Approved by a member of the DoveMed Editorial Board
First uploaded: Oct. 9, 2016
Last updated: Oct. 9, 2016