What are the other Names for this Test? (Equivalent Terms)
- ErbB-4 Protein Mutation Analysis
- HER4 Gene Mutation Analysis
- HER4 Test
What is HER4 Receptor Test? (Background Information)
- HER4 is found on the surface of tumors. It helps in the growth and spread of the tumor cells. The HER4 gene mutation can be present in breast cancer, prostate cancer, and childhood medulloblastoma
- HER4 Receptor Test is used for determining the choice of chemotherapy medication and to determine the prognosis of the tumor
What are the Clinical Indications for performing the HER4 Receptor Test?
Following are the clinical indications for performing the HER4 Receptor Test:
- To determine the prognosis and treatment options for chemotherapy in certain cases of breast cancer, prostate cancer, and childhood medulloblastoma
- This testing can be performed either at the time of diagnosis of the cancer or on its metastasis or recurrence
How is the Specimen Collected for HER4 Receptor Test?
Following is the specimen collection process for HER4 Receptor Test:
Sample required: Tissue biopsy from site of breast cancer, prostate cancer, and childhood medulloblastoma.
Process: A sample of tissue is obtained by inserting a needle into the site of the suspected tumor and aspirating a sample of cells (fine needle aspiration cytology or FNAC). It may also be obtained through a surgical biopsy of the tumor. Biopsy of metastatic cancer can also be used for receptor status testing.
Preparation required: No special preparation is needed prior to the test.
What is the Significance of the HER4 Receptor Test Result?
- The presence of a HER4 receptor mutation can potentially help in making the choice of chemotherapy medication
The laboratory test results are NOT to be interpreted as results of a "stand-alone" test. The test results have to be interpreted after correlating with suitable clinical findings and additional supplemental tests/information. Your healthcare providers will explain the meaning of your tests results, based on the overall clinical scenario.
Additional and Relevant Useful Information:
- The human epidermal growth factor receptor (HER) includes 4 receptors, namely HER1, HER2, HER3, and HER4
- The HER pathways are important in the field of oncology (study of cancer). These help in the signaling pathway of cellular growth and proliferation
Certain medications that you may be currently taking may influence the outcome of the test. Hence, it is important to inform your healthcare provider of the complete list of medications (including any herbal supplements) you are currently taking. This will help the healthcare provider interpret your test results more accurately and avoid unnecessary chances of a misdiagnosis.
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