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Hypoplasia of the Sacrum

Last updated March 7, 2018

Approved by: Maulik P. Purohit MD MPH

The topic Hypoplasia of the Sacrum you are seeking is a synonym, or alternative name, or is closely related to the medical condition Caudal Regression Syndrome.

Quick Summary:

  • Caudal Regression Syndrome is a genetic disorder that is characterised by impaired development of the posterior (tail/caudal) part of the body. Since the disorder affects the posterior part of the body, the gastrointestinal, genitourinary, and skeletal systems may be affected
  • Caudal Regression Syndrome is considered to be a multifactorial disorder, which means that it is caused by both genetic and environmental factors, generally within the first 4 weeks of embryonic development. Having a mother with diabetes and a family history of the condition are both risk factors for developing the syndrome
  • Some scientists believe that Caudal Regression Syndrome is caused by a disruption of the mesoderm (middle layer of embryonic tissue), which can lead to impaired blood supply to the caudal region. Another theory suggests that an abnormal artery in the developing fetus’s abdomen hinders blood supply, ultimately causing improper development of the mesoderm
  • Some of the symptoms of Caudal Regression Syndrome include bone malformations of the vertebral column (including the spine), the pelvic bone, the long bones of the legs and feet, inguinal hernia, abnormal rotation of the intestine, blocked opening to the anus, malformed or absent kidneys, fused ureters, and absent genitalia
  • Severe cases can result in complications including breathing difficulty in newborns, congenital heart defects, and urination difficulties. In childhood and later stages of development, the affected individual may require prosthetic limbs and wheelchair in order to move around normally
  • A diagnosis of Caudal Regression Syndrome can be made through prenatal ultrasound and genetic testing. After birth, physical examinations and imaging studies are routinely performed to diagnose the type and extent of damage to lower parts of the body
  • There is no cure for Caudal Regression Syndrome and treatment is offered to correct the abnormalities. A coordinated effort made by a team of specialists and surgeons may be required in order to successfully manage the condition
  • The prognosis of Caudal Regression Syndrome is based on the severity of the signs and symptoms. Individuals with mild conditions are known to have normal intelligence and are able to lead a better quality of lives. In case of severe disorder, the prognosis can be poor and many newborns may die from the disorder

Please find comprehensive information on Caudal Regression Syndrome regarding definition, distribution, risk factors, causes, signs & symptoms, diagnosis, complications, treatment, prevention, prognosis, and additional useful information HERE.

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Reviewed and Approved by a member of the DoveMed Editorial Board
First uploaded: Aug. 7, 2017
Last updated: March 7, 2018