The topic Developmental Venous Anomalies of the Brain you are seeking is a synonym, or alternative name, or is closely related to the medical condition Venous Malformations of the Brain.

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• Venous Malformations (VM) of the Brain is a collection of abnormally-enlarged veins draining into a large vein in the brain. The pattern of vein development in this condition resembles the snakes on Medusa’s head (Greek mythology) and is often described as “caput medusae”
• In the brain, the network of veins work to drain the organ of deoxygenated blood. The venous malformations (or venous angiomas) are developmental anomalies that grow gradually and are considered benign. Although aberrant in structure, they are still functional and fully-integrated with the venous system
• In most cases, Venous Malformations of the Brain arises sporadically, with spontaneous mutation(s) in the TIE-2 gene. The mutation is not passed on to the next generation and exists only in the affected tissue. The risk factors for these spontaneous mutations are not known
• It is believed that in some cases, the TIE-2 mutations are inherited. Therefore, having a family history of the condition may be a risk factor for being diagnosed with the malformation
• Venous malformations are caused by errors in the formation of veins during fetal development. The vein walls in the brains of affected individuals also have insufficient smooth muscle cells, which may contribute to development of the anomaly
• Since the aberration in veins occurs during fetal development, the condition is present at birth, although it may not be manifested until adolescence or even later, when a rapid growth may be seen
• The signs and symptoms of Venous Malformations of the Brain may include hemorrhage, blood clot formation, ischemic stroke, and epilepsy. In some cases, the condition may remain silent and present no symptoms
• Since the condition develops gradually, it may often go undiagnosed. The diagnosis is made by physical examination, assessment of symptoms (if any), evaluation of personal and family medical history, through imaging studies, such as CT or MRI scans, and cerebral arteriography
• Venous Malformations by itself may not give rise to many complications, if it is solitary (seen in about 75% of the cases). However, in combination with other lesions, such as cavernous malformations (in about 20% the cases), many complications are known to arise, such as bleeding in the brain, numbness, paralysis, and speech and memory problems
• Since Venous Malformations of the Brain are typically benign, the general policy of management is a “wait and watch” approach. However, if there is a possibility of a mixed vascular malformation, such as coexistence with a cavernous malformation, then the treatment options may include surgical removal of the anomaly
• The number and location of Venous Malformations of the Brain, as well as the presence of other vascular malformations, determines its overall prognosis. In many cases, if venous malformations are solitary, the prognosis is typically good

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