What are the other Names for this Condition? (Also known as/Synonyms)

• Collagenous Fibroma

What is Desmoplastic Fibroblastoma? (Definition/Background Information)

• Desmoplastic Fibroblastoma is a rare, benign soft tissue tumor that is commonly observed in the upper arms and shoulders of middle-aged and older adults. It is also known as a Collagenous Fibroma
• Presently, no risk factors for Desmoplastic Fibroblastoma have been identified. The cause of tumor formation is also not well-understood, but certain chromosomal abnormalities may be implicated
• In many cases, no signs and symptoms are observed and a specific treatment may not be required. Large tumors may present cosmetic issues and emotional stress in the affected individuals
• A complete surgical removal of Desmoplastic Fibroblastoma can result in a cure. This may be necessary for tumors that cause significant signs and symptoms and are large in size
• The prognosis of Desmoplastic Fibroblastoma is excellent on suitable surgical treatment (when required), since it is a benign condition. There is no risk of tumor recurrence

Who gets Desmoplastic Fibroblastoma? (Age and Sex Distribution)

• Desmoplastic Fibroblastoma is commonly seen in middle-age and older adults (40-70 years); 7 in 10 cases of Desmoplastic Fibroblastoma occur in this age group
• It is rarely observed during childhood and adolescence
• Individuals of both genders (males and females) are affected, but there is a male predilection and the male-female ratio is 2:1
• The tumor is seen in individuals of all races and ethnic groups

What are the Risk Factors for Desmoplastic Fibroblastoma? (Predisposing Factors)

• The risk factors for Desmoplastic Fibroblastoma are generally unknown

It is important to note that having a risk factor does not mean that one will get the condition. A risk factor increases ones chances of getting a condition compared to an individual without the risk factors. Some risk factors are more important than others.

Also, not having a risk factor does not mean that an individual will not get the condition. It is always important to discuss the effect of risk factors with your healthcare provider.

What are the Causes of Desmoplastic Fibroblastoma? (Etiology)

• Desmoplastic Fibroblastoma is a benign tumor of unknown cause
• A study of the tumor cells has revealed certain chromosomal abnormalities (translocations). These abnormalities may contribute towards research on the cause of tumor formation

What are the Signs and Symptoms of Desmoplastic Fibroblastoma?

Desmoplastic Fibroblastoma tumors are present as slow-growing masses below the skin tissues (subcutaneous presentation). The tumor can involve the skeletal muscles and connective tissues. A majority of the tumors do not present any signs and symptoms and may be discovered incidentally.

In case of significant signs and symptoms, the following may be noted:

• The presence of a small 1-4 cm sized, firm mass; some tumors are known to grow as large as 20 cm (along the greater dimension)
• The tumors are well-circumscribed with defined margins; they are oval-to-spindle shape in appearance
• The tumors may invade local fatty tissues and muscles; in very rare cases, the tumors may be entirely found within the muscles
• Desmoplastic Fibroblastomas are mostly observed in the upper arm, shoulder, legs, back, forearm, and hands/feet

How is Desmoplastic Fibroblastoma Diagnosed?

Desmoplastic Fibroblastoma diagnosis may involve the following tests and exams:

• Physical examination and evaluation of medical history
• Radiological studies of the affected region, such as MRI and CT scans
• Tissue biopsy of tumor specimen: A tissue biopsy is performed and sent to a laboratory for a pathological examination, who examines the biopsy under a microscope. After putting together clinical findings, special studies on tissues (if needed) and with microscope findings, the pathologist arrives at a definitive diagnosis

Many clinical conditions may have similar signs and symptoms. Your healthcare provider may perform additional tests to rule out other clinical conditions to arrive at a definitive diagnosis.

What are the possible Complications of Desmoplastic Fibroblastoma?

The possible complications from Desmoplastic Fibroblastoma include:

• Emotional stress due to concerns for cancer
• Cosmetic issues
• Tumors affecting the arms and legs (or hands and feet) may cause mobility issues or may restrict the free range of joint movement

How is Desmoplastic Fibroblastoma Treated?

• The treatment of Desmoplastic Fibroblastoma is a complete surgical excision, which can result in a cure. This may be considered for large-sized tumors presenting severe signs and symptoms
• In many cases, when the tumors are asymptomatic, no treatment may be necessary; a ‘wait and watch’ approach may be considered by the healthcare provider in such cases
• Regular follow-up visits and medical checkups are advised

How can Desmoplastic Fibroblastoma be Prevented?

Currently, Desmoplastic Fibroblastoma is a condition that is generally not preventable.

What is the Prognosis of Desmoplastic Fibroblastoma? (Outcomes/Resolutions)

• The prognosis of Desmoplastic Fibroblastoma is generally excellent after a local excisional surgery to remove the benign mass. The recurrence risk following tumor removal is almost absent
• Tumors that do not present any significant signs and symptoms need not be surgically treated

Additional and Relevant Useful Information for Desmoplastic Fibroblastoma:

Please visit our Cancer & Benign Tumor Health Center for more physician-approved health information:

http://www.dovemed.com/diseases-conditions/cancer/